serine hydroxymethyltransferase 2 ; Homo sapiens






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1 31178 Interaction of pyridoxal 5-phosphate with apo-serine hydroxymethyltransferase. Biochim Biophys Acta 1978 Oct 12 1
2 33702 Mechanism of serine hydroxymethylase catalyzed cleavage of L-erythro-beta-phenylserine: pH dependence of elementary kinetic processes from spectroscopic, pre-steady kinetic, and competitive inhibition studies. Biochemistry 1979 Mar 6 1
3 236734 Methylmalonic acidaemia and nonketotic hyperglycinaemia. Clinical and biochemical aspects. Arch Dis Child 1975 Feb 1
4 656448 Serine transhydroxymethylase. Equilibrium binding of folate analogs as active site probes. Biochim Biophys Acta 1978 May 11 4
5 921936 Purification and characterization of pyridoxal 5'-phosphate dependent serine hydroxymethylase from lamb liver and its action upon beta-phenylserines. Biochemistry 1977 Nov 29 1
6 921937 Studies of the reactions of lamb liver serine hydroxymethylase with L-phenylalanine: kinetic isotope effects upon quinonoid intermediate formation. Biochemistry 1977 Nov 29 2
7 921938 Studies of the reactions of substituted D,L-erythro-beta-phenylserines with lamb liver serine hydroxymethylase. Effects of substituents upon the dealdolization step. Biochemistry 1977 Nov 29 1
8 2105746 Disruption of thymidylate synthesis and glycine-serine interconversion by L-methionine and L-homocystine in Raji cells. Biochim Biophys Acta 1990 Jan 29 1
9 3165536 Mutation induction and relative biological effectiveness of neutrons in mammalian cells. Experimental observations. Radiat Res 1988 Aug 1
10 3499435 Isolation of a Ca-dependent erythrolytic protein (perforin) from cytotoxic T-lymphocytes. J Biochem 1987 Jul 1
11 6813440 Threonine metabolism of chicks fed threonine-imbalanced diets. J Nutr 1982 Nov 1
12 8284830 [Effect of pyrazole on the activity of acetaldehyde-producing enzymes in the liver]. Ukr Biokhim Zh (1978) 1993 Jul-Aug 1
13 10571879 Glycine and serine catabolism in non-photosynthetic higher plant cells: their role in C1 metabolism. Plant J 1999 Oct 3
14 10716626 Serine hydroxymethyltransferase and threonine aldolase: are they identical? Int J Biochem Cell Biol 2000 Mar 4
15 12163711 DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation. J Nutr 2002 Aug 2
16 13708237 Structural requirements of the tetrahydropteridine cofactor for the serine aldolase and the thymidylate synthetase reactions. Biochem Biophys Res Commun 1960 Dec 1
17 19179765 Branch-point stoichiometry can generate weak links in metabolism: the case of glycine biosynthesis. J Biosci 2008 Dec 2
18 20093739 A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis. J Biosci 2009 Dec 2
19 21876188 Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc Natl Acad Sci U S A 2011 Sep 13 6
20 22220685 Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization. J Neurochem 2012 Mar 2
21 22461784 Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma. Front Genet 2012 1
22 23474074 Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection. Med Hypotheses 2013 May 7
23 23550784 Mechanistic perspective on the relationship between pyridoxal 5'-phosphate and inflammation. Nutr Rev 2013 Apr 1
24 24700805 Role in tumor growth of a glycogen debranching enzyme lost in glycogen storage disease. J Natl Cancer Inst 2014 Apr 3 1
25 24755469 Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes. Cancer Res 2014 Jun 1 2
26 25186948 Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov 2014 Dec 11
27 25412303 SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation. Cell Death Dis 2014 Nov 20 3
28 25855294 SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature 2015 Apr 16 6
29 25999742 Positive correlation between expression level of mitochondrial serine hydroxymethyltransferase and breast cancer grade. Onco Targets Ther 2015 6
30 26103880 miR-370 and miR-373 regulate the pathogenesis of osteoarthritis by modulating one-carbon metabolism via SHMT-2 and MECP-2, respectively. Aging Cell 2015 Oct 1
31 26384269 Late stage modification of receptors identified from dynamic combinatorial libraries. Org Biomol Chem 2015 Nov 28 3
32 26482881 NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nat Genet 2015 Dec 3
33 26717037 A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells. Oncotarget 2016 Jan 26 1
34 26824641 Glycine supplementation in vitro enhances porcine preimplantation embryo cell number and decreases apoptosis but does not lead to live births. Mol Reprod Dev 2016 Mar 12
35 26900062 New Mechanism of Bone Cancer Pain: Tumor Tissue-Derived Endogenous Formaldehyde Induced Bone Cancer Pain via TRPV1 Activation. Adv Exp Med Biol 2016 1
36 26975021 Metabolic phenotype of bladder cancer. Cancer Treat Rev 2016 Apr 8
37 27343244 'Rod and ring' formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway. J Cell Sci 2016 Aug 1 4
38 27388843 Distribution of Threonine Aldolase Activity with Different Stereospecificities in Aerobic Bacteria. Biosci Biotechnol Biochem 1998 1
39 27391339 Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma. Oncotarget 2016 Aug 16 10
40 27530298 Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming. Biochim Biophys Acta 2016 Nov 4
41 27666119 Prognostic and therapeutic value of mitochondrial serine hydroxyl-methyltransferase 2 as a breast cancer biomarker. Oncol Rep 2016 Nov 3
42 28259896 The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review). Int J Oncol 2017 Apr 4
43 28794642 Overexpression of mitochondrial serine hydroxyl-methyltransferase 2 is associated with poor prognosis and promotes cell proliferation and invasion in gliomas. Onco Targets Ther 2017 2
44 29180469 SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation. Cancer Res 2018 Jan 15 5
45 29321536 Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis. Sci Rep 2018 Jan 10 2
46 29364879 Mitochondrial translation requires folate-dependent tRNA methylation. Nature 2018 Feb 1 4
47 29452640 Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs. Mol Cell 2018 Feb 15 9
48 29791506 SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy. PLoS Pathog 2018 May 2
49 29942251 Analysis of Gene Expression Variance in Schizophrenia Using Structural Equation Modeling. Front Mol Neurosci 2018 1
50 29991441 Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes. Arch Biochem Biophys 2018 Sep 1 1