Protein Name fragile histidine triad diadenosine triphosphatase
Organism Homo sapiens
Gene ID 2272
Gene Symbol


UniProt P49789 (FHIT_HUMAN), A0A024R366 (A0A024R366_HUMAN)
Relationships Total Number of functionally related compound(s) : 177
Total Number of Articles : 366

fragile histidine triad diadenosine triphosphatase

Gene Summary

The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]

  • bis(5'-adenosyl)-triphosphatase
  • AP3A hydrolase
  • adenosine 5'-monophosphoramidase FHIT
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