Protein Name Harvey rat sarcoma virus oncogene
Organism Mus musculus
Gene ID 15461
Gene Symbol

Hras

UniProt Q61411 (RASH_MOUSE)
Relationships Total Number of functionally related compound(s) : 366
Total Number of Articles : 484
Description

Harvey rat sarcoma virus oncogene

Gene Summary

Enables GTP binding activity. Involved in Ras protein signal transduction. Acts upstream of or within several processes, including defense response to protozoan; intracellular signal transduction; and positive regulation of interferon-gamma production. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in glutamatergic synapse and plasma membrane. Is expressed in several structures, including central nervous system; early embryo; metanephros; sensory organ; and tooth. Used to study Costello syndrome; high grade glioma; and malignant astrocytoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • GTPase HRas
  • H-Ras-1
  • H-ras 1 protein
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Properties