Protein Name caspase 3
Organism Mus musculus
Gene ID 12367
Gene Symbol


UniProt P70677 (CASP3_MOUSE)
Relationships Total Number of functionally related compound(s) : 1791
Total Number of Articles : 3292

caspase 3

Gene Summary

This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through apoptosis. Members of this family contain an N-terminal pro-domain and require cleavage at specific aspartate residues to become mature. The protein encoded by this gene belongs to a subgroup of cysteinyl aspartate-specific proteases that are activated by initiator caspases and that perform the proteolytic cleavage of apoptotic target proteins. Mice defective for this gene exhibit a variety of phenotypes including reduced neuronal apoptosis resulting in hyperplasias, hearing loss, attenuated osteogenic differentiation of bone marrow stromal stem cells, and pre- and post-natal lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

  • caspase-3
  • SREBP cleavage activity 1
  • apopain
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