Protein Name GTP cyclohydrolase 1
Organism Rattus norvegicus
Gene ID 29244
Gene Symbol


UniProt P22288 (GCH1_RAT)
Relationships Total Number of functionally related compound(s) : 97
Total Number of Articles : 119

GTP cyclohydrolase 1

Gene Summary

Enables several functions, including GTP binding activity; GTP cyclohydrolase I activity; and metal ion binding activity. Involved in several processes, including dihydrobiopterin metabolic process; response to pain; and vasodilation. Part of protein-containing complex. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia B; bipolar disorder; dystonia; and dystonia 5. Orthologous to human GCH1 (GTP cyclohydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]

  • GTP cyclohydrolase 1
  • GTP cyclohydrase I
  • GTP cyclohydrolase I
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