| Protein Name | GTP cyclohydrolase 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 29244 |
| Gene Symbol | Gch1 |
| UniProt | P22288 (GCH1_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
97
Total Number of Articles : 119 |
Description |
GTP cyclohydrolase 1 |
| Gene Summary |
Enables several functions, including GTP binding activity; GTP cyclohydrolase I activity; and metal ion binding activity. Involved in several processes, including dihydrobiopterin metabolic process; negative regulation of cellular senescence; and regulation of apoptotic process. Located in mitochondrion and nucleus. Part of intracellular protein-containing complex. Used to study Parkinsonism; cerebral infarction; hypertension; myocardial infarction; and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); liver disease (multiple); middle cerebral artery infarction; pulmonary fibrosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; movement disease (multiple); sickle cell anemia; and type 2 diabetes mellitus. Orthologous to human GCH1 (GTP cyclohydrolase 1). [provided by Alliance of Genome Resources, Jun 2025] |
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