GTP cyclohydrolase 1 ; Rattus norvegicus






119 Article(s)
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1 1281471 Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle. J Biol Chem 1992 Dec 25 7
2 1459137 Allosteric characteristics of GTP cyclohydrolase I from Escherichia coli. Eur J Biochem 1992 Dec 1 1
3 1551827 The mtrAB operon of Bacillus subtilis encodes GTP cyclohydrolase I (MtrA), an enzyme involved in folic acid biosynthesis, and MtrB, a regulator of tryptophan biosynthesis. J Bacteriol 1992 Apr 2
4 1563478 Control of cell-cycle-associated tetrahydrobiopterin synthesis in rat thymocytes. Exp Cell Res 1992 May 2
5 1985963 Cloning and sequencing of cDNA encoding rat GTP cyclohydrolase I. The first enzyme of the tetrahydrobiopterin biosynthetic pathway. J Biol Chem 1991 Jan 15 3
6 2484967 Regulation of GTP cyclohydrolase I and dihydropteridine reductase in rat pheochromocytoma PC 12 cells. J Enzyme Inhib 1989 12
7 2557335 Purification and characterization of rat liver GTP cyclohydrolase I. Cooperative binding of GTP to the enzyme. J Biol Chem 1989 Dec 25 1
8 2775176 Effects of sepiapterin and 6-acetyldihydrohomopterin on the guanosine triphosphate cyclohydrolase I of mouse, rat and the fruit-fly Drosophila. Biochem J 1989 May 15 2
9 3349105 Inhibition of GTP cyclohydrolase I by pterins. Biochim Biophys Acta 1988 Apr 14 1
10 3706734 A sensitive assay of GTP cyclohydrolase I activity in rat and human tissues using radioimmunoassay of neopterin. Anal Biochem 1986 Apr 7
11 7512954 Regulation of tetrahydrobiopterin biosynthesis in cultured dopamine neurons by depolarization and cAMP. J Biol Chem 1994 Apr 22 1
12 7531790 Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1 beta-stimulated rat glomerular mesangial cells. Kidney Int 1994 Nov 5
13 7675013 Brain biopterin metabolism in chronic experimental hepatic encephalopathy. Metab Brain Dis 1995 Jun 5
14 7689840 GTP cyclohydrolase I mRNA is induced by LPS in vascular smooth muscle: characterization, sequence and relationship to nitric oxide synthase. Biochem Biophys Res Commun 1993 Aug 31 8
15 7802762 Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle. Am J Physiol 1994 Apr 7
16 7820064 A comparison of the developing dopamine neuron phenotype in cultures of embryonic rat mesencephalon and hypothalamus. Neurochem Int 1994 Oct 2
17 8103077 Tetrahydrobiopterin cofactor biosynthesis: GTP cyclohydrolase I mRNA expression in rat brain and superior cervical ganglia. J Neurochem 1993 Sep 12
18 8602831 Inhibition of tetrahydrobiopterin synthesis reduces in vivo nitric oxide production in experimental endotoxic shock. Biochem Biophys Res Commun 1996 Mar 7 4
19 8632180 Regulation of GTP cyclohydrolase I gene expression and tetrahydrobiopterin content in cultured sympathetic neurons by leukemia inhibitory factor and ciliary neurotrophic factor. J Neurochem 1996 Jun 3
20 8699255 Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts. J Neurosci 1996 Jul 15 4
21 8702680 Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP. J Biol Chem 1996 Aug 16 11
22 8720483 Pyrrolidine dithiocarbamate inhibits immunostimulant-induced tetrahydrobiopterin synthesis in rat vascular smooth muscle. Eur J Pharmacol 1996 Jan 18 4
23 8792338 Tetrahydrobiopterin biosynthesis in the rat brain: heterogeneity of GTP cyclohydrolase I mRNA expression in monoamine-containing neurons. Neurochem Int 1996 May-Jun 18
24 8809061 Interleukin 1 beta and cAMP trigger the expression of GTP cyclohydrolase I in rat renal mesangial cells. Biochem J 1996 Sep 1 13
25 8853274 Tetrahydrobiopterin and GTP cyclohydrolase I in a rat model of endotoxic shock: relation to nitric oxide synthesis. Exp Physiol 1996 Jul 2
26 9092499 GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expression. J Biol Chem 1997 Apr 11 2
27 9271305 Expression of nitric oxide synthases and GTP cyclohydrolase I in the ventilatory and limb muscles during endotoxemia. Am J Respir Cell Mol Biol 1997 Aug 2
28 9277482 Induction of tetrahydrobiopterin synthesis in rat cardiac myocytes: impact on cytokine-induced NO generation. Am J Physiol 1997 Aug 4
29 9332722 Glucocorticoids elevate GTP cyclohydrolase I mRNA levels in vivo and in PC12 cells. Brain Res Mol Brain Res 1997 Sep 13
30 9336394 Parathyroid hormone-related protein upregulates interleukin-1beta-induced nitric oxide synthesis. Hypertension 1997 Oct 1
31 9351511 Differential effect of dexamethasone on interleukin 1beta- and cyclic AMP-triggered expression of GTP cyclohydrolase I in rat renal mesangial cells. Br J Pharmacol 1997 Oct 5
32 9444617 Regulation of inducible nitric oxide synthase (iNOS) and GTP cyclohydrolase I (GTP-CH I) gene expression by ox-LDL in rat vascular smooth muscle cells. J Physiol Pharmacol 1997 Dec 1
33 9628761 In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase. Exp Neurol 1998 Jun 5
34 9636709 Rat GTP cyclohydrolase I is a homodecameric protein complex containing high-affinity calcium-binding sites. J Mol Biol 1998 May 29 3
35 9694862 GTP cyclohydrolase I inhibition by the prototypic inhibitor 2, 4-diamino-6-hydroxypyrimidine. Mechanisms and unanticipated role of GTP cyclohydrolase I feedback regulatory protein. J Biol Chem 1998 Aug 14 13
36 9705293 Phosphorylation of GTP cyclohydrolase I and modulation of its activity in rodent mast cells. GTP cyclohydrolase I hyperphosphorylation is coupled to high affinity IgE receptor signaling and involves protein kinase C. J Biol Chem 1998 Aug 21 6
37 9787239 Immobilization Stress Elevates GTP Cyclohydrolase I mRNA Levels in Rat Adrenals Predominantly by Hormonally Mediated Mechanisms. Stress 1997 May 8
38 9790990 Protein kinase C phosphorylates and activates GTP cyclohydrolase I in rat renal mesangial cells. Biochem Biophys Res Commun 1998 Oct 29 3
39 9843157 Self-protection of PC12 cells by 6R-tetrahydrobiopterin from nitric oxide toxicity. J Neurosci Res 1998 Dec 1 4
40 9920651 Blockade of tetrahydrobiopterin synthesis protects neurons after transient forebrain ischemia in rat: a novel role for the cofactor. J Neurosci 1999 Feb 1 2
41 9930739 GTP cyclohydrolase I feedback regulatory protein is expressed in serotonin neurons and regulates tetrahydrobiopterin biosynthesis. J Neurochem 1999 Feb 16
42 10381000 Tryptophan hydroxylase mRNA levels are elevated by repeated immobilization stress in rat raphe nuclei but not in pineal gland. Neurosci Lett 1999 Jun 4 3
43 10574472 Oxidized low density lipoprotein inhibits inducible nitric oxide synthase, GTP cyclohydrolase I and transforming growth factor beta gene expression in rat macrophages. J Physiol Pharmacol 1999 Sep 3
44 10615404 Adrenomedullin augments nitric oxide and tetrahydrobioptein synthesis in cytokine-stimulated vascular smooth muscle cells. Cardiovasc Res 1999 Oct 1
45 10622266 Presence of excess tetrahydrobiopterin during nitric oxide production from inducible nitric oxide synthase in LPS-treated rat aorta. Life Sci 1999 8
46 10681588 Identification and characterization of basal and cyclic AMP response elements in the promoter of the rat GTP cyclohydrolase I gene. J Biol Chem 2000 Feb 25 2
47 11436352 Gene therapy for Parkinson's disease: determining the genes necessary for optimal dopamine replacement in rat models. Hum Cell 2001 Mar 2
48 11580249 Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP. J Mol Biol 2001 Oct 5 2
49 12051753 Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells. Biochem Biophys Res Commun 2002 May 10 4
50 12358737 A site-specific mutation of tyrosine hydroxylase reduces feedback inhibition by dopamine in genetically modified cells grafted in parkinsonian rats. J Neurochem 2002 Oct 7