| Protein Name | nucleophosmin 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 18148 |
| Gene Symbol | Npm1 |
| UniProt | Q61937 (NPM_MOUSE), Q5SQB7 (Q5SQB7_MOUSE), Q9DAY9 (Q9DAY9_MOUSE), Q5BL09 (Q5BL09_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
56
Total Number of Articles : 50 |
Description |
nucleophosmin 1 |
| Gene Summary |
Enables identical protein binding activity and rRNA binding activity. Involved in positive regulation of protein localization to nucleolus; positive regulation of transcription by RNA polymerase II; and protein stabilization. Acts upstream of or within several processes, including positive regulation of centrosome duplication; regulation of macromolecule metabolic process; and ribosome biogenesis. Located in centrosome; cytosol; and nuclear lumen. Part of large ribosomal subunit and small ribosomal subunit. Is expressed in several structures, including early conceptus; neural tube; oocyte; small intestine crypt of lieberkuhn; and telencephalon. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1). [provided by Alliance of Genome Resources, Jul 2025] |
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