Pim-1 proto-oncogene, serine/threonine kinase ; Homo sapiens






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1 315708 An alpha 1-antitrypsin variant, Pi B Alhambra (Lys to Asp, Glu to Asp), with rapid anodal electrophoretic mobility. Am J Hum Genet 1979 Sep 2
2 317068 Characterization of alpha-1-antitrypsin by isoelectric focusing on an ultrathin polyacrylamide gel layer. An economic high-resolution system for determining PiM subtypes. Hum Genet 1979 1
3 1474276 Serological response to purified mycobacterial phosphatidylinositol mannoside in healthy controls and in patients with tuberculosis and leprosy. Int J Lepr Other Mycobact Dis 1992 Sep 2
4 1713213 Recombinant human pim-1 protein exhibits serine/threonine kinase activity. J Biol Chem 1991 Jul 25 14
5 1844237 Spi1 GTPase interacts with RCC1 to maintain interdependency of cell cycle events. Princess Takamatsu Symp 1991 3
6 3429489 Cloning and characterization of the human PIM-1 gene: a putative oncogene related to the protein kinases. J Cell Biochem 1987 Oct 2
7 6608973 The oligosaccharides of human alpha 1-antitrypsin. Can J Biochem Cell Biol 1984 Jan 1
8 6610464 Preparation and examination of the oligosaccharides of serum alpha 1-antitrypsin PiZ. Can J Biochem Cell Biol 1984 May 1
9 7527668 Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor. Blood 1994 Dec 15 1
10 7594647 Differentiation-associated expression of the proto-oncogene pim-1 in cultured human keratinocytes. J Invest Dermatol 1995 Nov 4
11 7704900 Expression of the pim-1 protooncogene: differential inducibility between alpha/beta- and gamma/delta-T cells and B cells. Cell Immunol 1995 Apr 15 8
12 7734939 Alpha beta chimeric antisense oligonucleotides: synthesis and nuclease resistance in biological media. Antisense Res Dev 1994 Winter 1
13 7957078 Molecular chaperones cooperate with PIM1 protease in the degradation of misfolded proteins in mitochondria. EMBO J 1994 Nov 1 1
14 7958988 In vitro inhibition of the pim-1 protooncogene by chimeric oligodeoxyribonucleotides composed of alpha- and beta-anomeric fragments. Gene 1994 Nov 4 1
15 8477700 Intracellular retention and degradation of human mutant variant of a alpha 1-antitrypsin in stably transfected Chinese hamster ovary cell lines. Eur J Biochem 1993 Apr 1 1
16 8543805 pim-1 proto-oncogene expression in anti-CD3-mediated T cell activation is associated with protein kinase C activation and is independent of Raf-1. J Immunol 1996 Jan 15 2
17 8660654 Ubiquitous expression and cell cycle regulation of the protein kinase PIM-1. Arch Biochem Biophys 1996 Jun 15 1
18 9250363 Phosphorylation site substrate specificity determinants for the Pim-1 protooncogene-encoded protein kinase. Biochem Cell Biol 1997 10
19 9405361 Autocatalytic processing of the ATP-dependent PIM1 protease: crucial function of a pro-region for sorting to mitochondria. EMBO J 1997 Dec 15 3
20 9504913 The identification of cDNAs that affect the mitosis-to-interphase transition in Schizosaccharomyces pombe, including sbp1, which encodes a spi1p-GTP-binding protein. Genetics 1998 Feb 1
21 9853146 Percutaneous mitoxantrone injection for primary and secondary liver tumors: preliminary results. Cardiovasc Intervent Radiol 1998 Sep-Oct 1
22 10664448 Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1). FEBS Lett 2000 Feb 4 3
23 10931201 PAP-1, a novel target protein of phosphorylation by pim-1 kinase. Eur J Biochem 2000 Aug 2
24 11237709 Regulation of Pim-1 by Hsp90. Biochem Biophys Res Commun 2001 Mar 2 2
25 11322935 Inhibition of T-cell invasion across cultured fibroblast monolayers by phenothiazine-related calmodulin inhibitors: impairment of lymphocyte motility by trifluoperazine and chlorpromazine, and alteration of the monolayer by pimozide. Biochem Pharmacol 2001 May 15 1
26 11368509 Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells. Arch Biochem Biophys 2001 Jun 1 2
27 11823475 Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase. J Immunol 2002 Feb 15 1
28 11890657 Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages. Ann Rheum Dis 2001 Nov 1
29 12111331 Pim-1 associates with protein complexes necessary for mitosis. Chromosoma 2002 Jul 1
30 12431783 Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase. Biochim Biophys Acta 2002 Dec 16 4
31 12473674 Protein phosphatase 2A regulates the stability of Pim protein kinases. J Biol Chem 2003 Feb 14 1
32 14565478 Covalent coupling of a PIM-1 oncogene targeted PNA with an antennapedia derived peptide. Nucleosides Nucleotides Nucleic Acids 2003 May-Aug 1
33 14627436 Biosynthesis of mycobacterial phosphatidylinositol mannosides. Biochem J 2004 Mar 1 2
34 14981536 Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells. Oncogene 2004 Mar 11 2
35 15525646 Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase. J Biol Chem 2005 Feb 18 7
36 15634688 Function of phosphatidylinositol in mycobacteria. J Biol Chem 2005 Mar 25 2
37 15642745 The Pim kinases control rapamycin-resistant T cell survival and activation. J Exp Med 2005 Jan 17 2
38 15657054 Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002. J Biol Chem 2005 Apr 8 6
39 15798097 Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway. Mol Cancer Res 2005 Mar 3
40 15802333 Endothelial interactions of neutrophils under flow in chronic obstructive pulmonary disease. Eur Respir J 2005 Apr 1
41 15808862 Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma. J Mol Biol 2005 Apr 22 6
42 16186805 The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs. Oncogene 2006 Jan 5 1
43 16227208 Structure and substrate specificity of the Pim-1 kinase. J Biol Chem 2005 Dec 16 3
44 16302800 Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. J Med Chem 2005 Dec 1 6
45 16356754 The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C. Int J Biochem Cell Biol 2006 Mar 1
46 16381041 Ruthenium half-sandwich complexes bound to protein kinase Pim-1. Angew Chem Int Ed Engl 2006 Feb 27 1
47 16417378 Rapid access to unexplored chemical space by ligand scanning around a ruthenium center: discovery of potent and selective protein kinase inhibitors. J Am Chem Soc 2006 Jan 25 1
48 16455649 Identification of a novel protein with a role in lipoarabinomannan biosynthesis in mycobacteria. J Biol Chem 2006 Apr 7 4
49 16616857 Thalidomide alters c-MYB and PIM-1 signaling in K-562 cells. Pharmacol Res 2006 Aug 3
50 17107048 Ruthenium half-sandwich complexes as protein kinase inhibitors: an N-succinimidyl ester for rapid derivatizations of the cyclopentadienyl moiety. Org Lett 2006 Nov 23 3