Protein Name FK506 binding protein 1b
Organism Mus musculus
Gene ID 14226
Gene Symbol

Fkbp1b

UniProt Q9Z2I2 (FKB1B_MOUSE), A9E3L2 (A9E3L2_MOUSE), Q80YE1 (Q80YE1_MOUSE), Q810R7 (Q810R7_MOUSE)
Relationships Total Number of functionally related compound(s) : 28
Total Number of Articles : 28
Description

FK506 binding protein 1b

Gene Summary

Enables FK506 binding activity; peptidyl-prolyl cis-trans isomerase activity; and transmembrane transporter binding activity. Involved in negative regulation of heart rate and regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion. Acts upstream of or within several processes, including insulin secretion; negative regulation of insulin secretion involved in cellular response to glucose stimulus; and neuronal action potential propagation. Located in sarcoplasmic reticulum membrane. Part of calcium channel complex. Is expressed in male reproductive gland or organ and nervous system. Used to study catecholaminergic polymorphic ventricular tachycardia. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to human FKBP1B (FKBP prolyl isomerase 1B). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • peptidyl-prolyl cis-trans isomerase FKBP1B
  • 12.6 kDa FK506-binding protein
  • 12.6 kDa FKBP
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Properties