Protein Name SMAD specific E3 ubiquitin protein ligase 1
Organism Homo sapiens
Gene ID 57154
Gene Symbol

SMURF1

UniProt Q9HCE7 (SMUF1_HUMAN)
Relationships Total Number of functionally related compound(s) : 47
Total Number of Articles : 48
Description

SMAD specific E3 ubiquitin protein ligase 1

Gene Summary

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]

synonyms
  • E3 ubiquitin-protein ligase SMURF1
  • E3 ubiquitin ligase SMURF1
  • HECT-type E3 ubiquitin transferase SMURF1
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Properties