| Protein Name | transcription factor 7 like 2, T cell specific, HMG box |
|---|---|
| Organism | Mus musculus |
| Gene ID | 21416 |
| Gene Symbol | Tcf7l2 |
| UniProt | Q924A0 (TF7L2_MOUSE), D3YWT3 (D3YWT3_MOUSE), A0A0R4J1G0 (A0A0R4J1G0_MOUSE), E9Q990 (E9Q990_MOUSE), F6WBK9 (F6WBK9_MOUSE), E9QQ90 (E9QQ90_MOUSE), F6WPX2 (F6WPX2_MOUSE), Q8CAI6 (Q8CAI6_MOUSE), Q8BS68 (Q8BS68_MOUSE), E9QQ91 (E9QQ91_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
25
Total Number of Articles : 33 |
Description |
transcription factor 7 like 2, T cell specific, HMG box |
| Gene Summary |
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in several processes, including canonical Wnt signaling pathway; positive regulation of insulin secretion; and response to glucose. Acts upstream of or within several processes, including embryonic morphogenesis; negative regulation of cellular response to growth factor stimulus; and nervous system development. Located in cytosol and nucleus. Part of catenin-TCF7L2 complex and transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2). [provided by Alliance of Genome Resources, Jun 2025] |
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