Protein Name U2 small nuclear RNA auxiliary factor 1
Organism Homo sapiens
Gene ID 7307
Gene Symbol

U2AF1

UniProt Q01081 (U2AF1_HUMAN), P0DN76 (U2AF5_HUMAN), Q7Z780 (Q7Z780_HUMAN)
Relationships Total Number of functionally related compound(s) : 24
Total Number of Articles : 30
Description

U2 small nuclear RNA auxiliary factor 1

Gene Summary

This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

synonyms
  • splicing factor U2AF 35 kDa subunit
  • U2 small nuclear RNA auxillary factor 1
  • U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit
Click to show/hide the synonyms
Properties