| Protein Name | checkpoint kinase 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 50883 |
| Gene Symbol | Chek2 |
| UniProt | Q9Z265 (CHK2_MOUSE), Q543W6 (Q543W6_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
56
Total Number of Articles : 62 |
Description |
checkpoint kinase 2 |
| Gene Summary |
Enables protein kinase activity. Acts upstream of or within several processes, including cellular response to gamma radiation; signal transduction by p53 class mediator; and thymocyte apoptotic process. Predicted to be located in Golgi apparatus and PML body. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including central nervous system; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Orthologous to human CHEK2 (checkpoint kinase 2). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |