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| 2 | 12192050 | Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. | Mol Cell Biol | 2002 Sep |
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| 3 | 12356735 | Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. | EMBO J | 2002 Oct 1 |
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| 4 | 14752107 | DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage. | J Biol Chem | 2004 Apr 9 |
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| 5 | 15485917 | Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1. | Mol Cell Biol | 2004 Nov |
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| 6 | 15632126 | The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1. | J Biol Chem | 2005 Mar 18 |
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| 7 | 17431115 | S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11-induced apoptosis of prostate cancer cells. | Mol Cancer Ther | 2007 Apr |
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| 8 | 17455238 | The molecular mechanisms of vitamin C on cell cycle regulation in B16F10 murine melanoma. | J Cell Biochem | 2007 Nov 1 |
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| 9 | 18162465 | ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. | J Biol Chem | 2008 Mar 7 |
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| 10 | 18167129 | Restoration of fragile histidine triad expression restores Chk2 activity in response to ionizing radiation in oral squamous cell carcinoma cells. | Cancer Sci | 2008 Mar |
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| 11 | 18936108 | Interference of cell cycle progression by zidovudine and lamivudine in NIH 3T3 cells. | Mutagenesis | 2009 Mar |
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| 12 | 20305300 | Rad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibition. | J Biol Chem | 2010 May 14 |
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| 13 | 20700484 | NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway. | PLoS One | 2010 Aug 5 |
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| 14 | 20820782 | Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity. | Cancer Chemother Pharmacol | 2011 Jul |
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| 15 | 21664921 | Point mutation at the Nbs1 Threonine 278 site does not affect mouse development, but compromises the Chk2 and Smc1 phosphorylation after DNA damage. | Mech Ageing Dev | 2011 Aug |
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| 16 | 21745814 | Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function. | Nucleic Acids Res | 2011 Oct |
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| 17 | 22030621 | Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition. | Cell Cycle | 2011 Oct 15 |
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| 18 | 22159226 | Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis. | Carcinogenesis | 2012 Feb |
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| 19 | 22313396 | P53 and its molecular basis to chemoresistance in breast cancer. | Expert Opin Ther Targets | 2012 Mar |
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| 20 | 22732306 | Cholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice. | J Steroid Biochem Mol Biol | 2012 Nov |
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| 21 | 23211021 | Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin. | BMC Cancer | 2012 Dec 4 |
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| 22 | 23667485 | Identification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potential. | PLoS One | 2013 |
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| 23 | 23851027 | Activation of ERK accelerates repair of renal tubular epithelial cells, whereas it inhibits progression of fibrosis following ischemia/reperfusion injury. | Biochim Biophys Acta | 2013 Dec |
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| 24 | 24553354 | Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells. | Oncotarget | 2014 Feb 15 |
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| 25 | 24726884 | DNA damage response in renal ischemia-reperfusion and ATP-depletion injury of renal tubular cells. | Biochim Biophys Acta | 2014 Jul |
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| 26 | 24853623 | Co-abrogation of Chk1 and Chk2 by potent oncolytic adenovirus potentiates the antitumor efficacy of cisplatin or irradiation. | Cancer Gene Ther | 2014 May |
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| 27 | 25319519 | Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and calcium-phosphate metabolism. | Pflugers Arch | 2015 Sep |
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| 28 | 25489053 | A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease. | Hum Mol Genet | 2015 Apr 1 |
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| 29 | 25520856 | Mahanine, a novel mitochondrial complex-III inhibitor induces G0/G1 arrest through redox alteration-mediated DNA damage response and regresses glioblastoma multiforme. | Am J Cancer Res | 2014 |
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| 30 | 26427872 | Maternal diabetes triggers DNA damage and DNA damage response in neurulation stage embryos through oxidative stress. | Biochem Biophys Res Commun | 2015 Nov 13 |
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| 31 | 26801745 | Uridine homeostatic disorder leads to DNA damage and tumorigenesis. | Cancer Lett | 2016 Mar 28 |
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| 32 | 26837068 | Guizhi Fuling Wan as a Novel Agent for Intravesical Treatment for Bladder Cancer in a Mouse Model. | Mol Med | 2016 Sep |
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| 33 | 27121056 | Targeting of Chk2 as a countermeasure to dose-limiting toxicity triggered by topoisomerase-II (TOP2) poisons. | Oncotarget | 2016 May 17 |
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| 34 | 27564101 | Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia. | Oncotarget | 2016 Oct 25 |
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| 35 | 27991505 | Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis. | Sci Rep | 2016 Dec 19 |
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| 36 | 28423495 | Afatinib radiosensitizes head and neck squamous cell carcinoma cells by targeting cancer stem cells. | Oncotarget | 2017 Mar 28 |
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| 37 | 28498365 | Inhibition of Twist1-mediated invasion by Chk2 promotes premature senescence in p53-defective cancer cells. | Cell Death Differ | 2017 Jul |
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| 38 | 28617799 | p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes. | PLoS Genet | 2017 Jun |
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| 39 | 29200877 | Microtubule-targeting agents can sensitize cancer cells to ionizing radiation by an interphase-based mechanism. | Onco Targets Ther | 2017 |
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| 40 | 29725001 | Ablation of beta subunit of protein kinase CK2 in mouse oocytes causes follicle atresia and premature ovarian failure. | Cell Death Dis | 2018 May 1 |
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| 41 | 29767555 | Protective effect of the BET protein inhibitor JQ1 in cisplatin-induced nephrotoxicity. | Am J Physiol Renal Physiol | 2018 Sep 1 |
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| 42 | 29988075 | Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies. | Cell Death Differ | 2019 Mar |
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| 43 | 30015873 | Effects of a checkpoint kinase inhibitor, AZD7762, on tumor suppression and bone remodeling. | Int J Oncol | 2018 Sep |
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| 44 | 30323964 | Anti-malarial atovaquone exhibits anti-tumor effects by inducing DNA damage in hepatocellular carcinoma. | Am J Cancer Res | 2018 |
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| 45 | 30537743 | Sodium Fluoride Arrests Renal G2/M Phase Cell-Cycle Progression by Activating ATM-Chk2-P53/Cdc25C Signaling Pathway in Mice. | Cell Physiol Biochem | 2018 |
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| 46 | 30693443 | ROS-Induced Activation of DNA Damage Responses Drives Senescence-Like State in Postmitotic Cochlear Cells: Implication for Hearing Preservation. | Mol Neurobiol | 2019 Aug |
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| 47 | 31209362 | SIRT1 modulates cell cycle progression by regulating CHK2 acetylation-phosphorylation. | Cell Death Differ | 2020 Feb |
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| 48 | 31520908 | BDE-209 induces male reproductive toxicity via cell cycle arrest and apoptosis mediated by DNA damage response signaling pathways. | Environ Pollut | 2019 Dec |
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| 49 | 31562295 | Kinase-independent inhibition of cyclophosphamide-induced pathways protects the ovarian reserve and prolongs fertility. | Cell Death Dis | 2019 Sep 27 |
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| 50 | 31599189 | Cholesterol depletion sensitizes gallbladder cancer to cisplatin by impairing DNA damage response. | Cell Cycle | 2019 Dec |
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