Protein Name 2'-5'-oligoadenylate synthetase 1
Organism Homo sapiens
Gene ID 4938
Gene Symbol


UniProt P00973 (OAS1_HUMAN)
Relationships Total Number of functionally related compound(s) : 40
Total Number of Articles : 31

2'-5'-oligoadenylate synthetase 1

Gene Summary

This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cellular processes like cell growth and apoptosis. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection, including SARS-CoV-2, and diabetes mellitus, type 1. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, May 2022]

  • 2'-5'-oligoadenylate synthase 1
  • (2-5')oligo(A) synthase 1
  • 2',5'-oligo A synthetase 1
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