| Protein Name | serine/threonine kinase 11 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 20869 |
| Gene Symbol | Stk11 |
| UniProt | Q9WTK7 (STK11_MOUSE), Q3V4A1 (Q3V4A1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
222
Total Number of Articles : 251 |
Description |
serine/threonine kinase 11 |
| Gene Summary |
This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014] |
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