Protein Name receptor interacting serine/threonine kinase 3
Organism Homo sapiens
Gene ID 11035
Gene Symbol

RIPK3

UniProt Q9Y572 (RIPK3_HUMAN)
Relationships Total Number of functionally related compound(s) : 184
Total Number of Articles : 215
Description

receptor interacting serine/threonine kinase 3

Gene Summary

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

synonyms
  • receptor-interacting serine/threonine-protein kinase 3
  • RIP-3
  • RIP-like protein kinase 3
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Properties