Protein Name T-box 21
Organism Mus musculus
Gene ID 57765
Gene Symbol

Tbx21

UniProt Q9JKD8 (TBX21_MOUSE)
Relationships Total Number of functionally related compound(s) : 133
Total Number of Articles : 138
Description

T-box 21

Gene Summary

Enables DNA binding activity. Involved in several processes, including negative regulation of T-helper 17 cell lineage commitment; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of gene expression. Acts upstream of or within T cell differentiation; cellular response to organic substance; and positive regulation of isotype switching to IgG isotypes. Located in neuronal cell body and nucleus. Is expressed in several structures, including central nervous system; colon; genitourinary system; sensory organ; and thymus. Used to study asthma. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human TBX21 (T-box transcription factor 21). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • T-box transcription factor TBX21
  • T-box protein 21
  • T-cell-specific T-box transcription factor T-bet
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Properties