Protein Name | Janus kinase 1 |
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Organism | Homo sapiens |
Gene ID | 3716 |
Gene Symbol | JAK1 |
UniProt | P23458 (JAK1_HUMAN), Q6P669 (Q6P669_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
379
Total Number of Articles : 1146 |
Description |
Janus kinase 1 |
Gene Summary |
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020] |
synonyms |
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Properties | |