Protein Name Janus kinase 1
Organism Homo sapiens
Gene ID 3716
Gene Symbol


UniProt P23458 (JAK1_HUMAN), Q6P669 (Q6P669_HUMAN)
Relationships Total Number of functionally related compound(s) : 379
Total Number of Articles : 1146

Janus kinase 1

Gene Summary

This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020]

  • tyrosine-protein kinase JAK1
  • JAK1A
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