Janus kinase 1 ; Homo sapiens






1146 Article(s)
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1 7504784 Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature 1993 Dec 9 2
2 7512720 Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. Proc Natl Acad Sci U S A 1994 Apr 12 2
3 7514165 Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor. J Biol Chem 1994 May 20 3
4 7517047 The Janus kinase family and signaling through members of the cytokine receptor superfamily. Proc Soc Exp Biol Med 1994 Jul 1
5 7525556 Differential tyrosine phosphorylation of JAK1, JAK2, and STAT1 by growth hormone and interferon-gamma in IM-9 cells. J Biol Chem 1994 Nov 4 2
6 7526154 Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. Mol Cell Biol 1994 Dec 1
7 7528775 Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J Exp Med 1995 Jan 1 1
8 7532278 Role of STAT2 in the alpha interferon signaling pathway. Mol Cell Biol 1995 Mar 1
9 7543512 IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes. J Immunol 1995 Aug 1 2
10 7544000 Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation. Proc Natl Acad Sci U S A 1995 Aug 15 1
11 7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc Natl Acad Sci U S A 1995 Sep 12 1
12 7569929 Jak-STAT signaling induced by the v-abl oncogene. Science 1995 Sep 29 2
13 7579336 Distinct regions of the granulocyte colony-stimulating factor receptor are required for tyrosine phosphorylation of the signaling molecules JAK2, Stat3, and p42, p44MAPK. Blood 1995 Nov 15 1
14 7579387 Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts. Blood 1995 Oct 15 1
15 7591091 Attenuation of gamma interferon-induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani: selective inhibition of signaling through Janus kinases and Stat1. Infect Immun 1995 Nov 5
16 7594533 Regulation of JAK3 expression and activation in human B cells and B cell malignancies. J Immunol 1995 Dec 1 1
17 7608217 Aromatase P450 gene expression in human adipose tissue. Role of a Jak/STAT pathway in regulation of the adipose-specific promoter. J Biol Chem 1995 Jul 7 1
18 7615558 The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors. J Biol Chem 1995 Jul 21 2
19 7657660 Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. J Biol Chem 1995 Sep 1 1
20 7713924 Transmembrane signaling by the alpha subunit of the type I interferon receptor is essential for activation of the JAK kinases and the transcriptional factor ISGF3. J Biol Chem 1995 Apr 7 1
21 7721895 Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha. J Biol Chem 1995 Apr 21 2
22 7756643 Tyrosine phosphorylation and activation of JAK family tyrosine kinases by interleukin-9 in MO7E cells. Blood 1995 Jun 1 1
23 7929242 Cell cycle-dependent modulation of alpha-interferon-inducible gene expression and activation of signaling components in Daudi cells. J Biol Chem 1994 Oct 14 2
24 7929391 JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes. J Biol Chem 1994 Oct 28 2
25 7935373 Erythropoietin and interleukin-2 activate distinct JAK kinase family members. Mol Cell Biol 1994 Oct 1
26 7957877 JAK3 Janus kinase is involved in interleukin 7 signal pathway. FEBS Lett 1994 Oct 24 2
27 7973658 Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID. Science 1994 Nov 11 1
28 7973659 Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 1994 Nov 11 2
29 7988557 Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes. EMBO J 1994 Dec 1 1
30 7995951 IgG immune complexes inhibit IFN-gamma-induced transcription of the Fc gamma RI gene in human monocytes by preventing the tyrosine phosphorylation of the p91 (Stat1) transcription factor. J Immunol 1995 Jan 1 1
31 8022486 Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 1994 Jul 14 3
32 8041779 Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains. Proc Natl Acad Sci U S A 1994 Jul 19 1
33 8536716 Involvement of Janus kinases in the insulin signaling pathway. Eur J Biochem 1995 Dec 1 1
34 8550573 The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2. J Biol Chem 1996 Jan 5 1
35 8550631 Identification of an interferon-gamma receptor alpha chain sequence required for JAK-1 binding. J Biol Chem 1996 Jan 5 1
36 8605323 Correction of interleukin-2 receptor function in X-SCID lymphoblastoid cells by retrovirally mediated transfer of the gamma-c gene. Blood 1996 Apr 15 1
37 8608222 The membrane-distal cytoplasmic region of human granulocyte colony-stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation. Blood 1996 Feb 15 1
38 8621573 STAT activation by epidermal growth factor (EGF) and amphiregulin. Requirement for the EGF receptor kinase but not for tyrosine phosphorylation sites or JAK1. J Biol Chem 1996 Apr 19 1
39 8625884 Activation of the JAK-STAT signal transduction pathway by oncostatin-M cultured human and mouse osteoblastic cells. Endocrinology 1996 Apr 1
40 8628273 Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction. Mol Cell Biol 1996 May 1
41 8647212 Dispensability of Jak1 tyrosine kinase for interleukin-2-induced cell growth signaling in a human T cell line. Eur J Immunol 1996 Jun 1
42 8657115 Inhibition of alpha interferon but not gamma interferon signal transduction by phorbol esters is mediated by a tyrosine phosphatase. Mol Cell Biol 1996 Apr 1
43 8671609 Critical proline residues of the cytoplasmic domain of the IL-5 receptor alpha chain and its function in IL-5-mediated activation of JAK kinase and STAT5. Int Immunol 1996 Feb 4
44 8683106 Differential utilization of Janus kinase-signal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-alpha. J Immunol 1996 Jul 1 1
45 8700538 Dimerization of a chimeric CD4-interferon-alpha receptor reconstitutes the signaling events preceding STAT phosphorylation. Oncogene 1996 Jul 4 1
46 8759739 Stat1 alpha expression is involved in IFN-gamma induction of the class II transactivator and class II MHC genes. J Immunol 1996 Aug 15 1
47 8770944 PDGF stimulates tyrosine phosphorylation of JAK 1 protein tyrosine kinase in human mesangial cells. Kidney Int 1996 Jan 3
48 8780896 Constitutive STAT1 tyrosine phosphorylation in U937 monocytes overexpressing the TYK2 protein tyrosine kinase does not induce gene transcription. Cell Growth Differ 1996 Jun 1
49 8864852 Signal transduction pathways for interleukin 4 and insulin in human hepatoma cells. J Biochem 1996 Jul 1
50 8887543 Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase. EMBO J 1996 Sep 2 1