CPRiL

Pten

phosphatase and tensin homolog

Enables several functions, including PDZ domain binding activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; dephosphorylation; and negative regulation of developmental growth. Located in dendritic spine and postsynaptic membrane. Is active in postsynaptic cytosol. Used to study portal hypertension and substance-related disorder. Biomarker of several diseases, including acute myocardial infarction; glucose metabolism disease (multiple); liver disease (multiple); retinal disease (multiple); and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog). [provided by Alliance of Genome Resources, Jul 2025]

• phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
• inositol polyphosphate 3-phosphatase
• mutated in multiple advanced cancers 1
phosphatase and tensin homolog deleted on chromosome ten
protein tyrosine phosphatase and tensin-like protein
MMAC1
Mmac
TEP1