| Protein Name | large tumor suppressor kinase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 9113 |
| Gene Symbol | LATS1 |
| UniProt | O95835 (LATS1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
70
Total Number of Articles : 70 |
Description |
large tumor suppressor kinase 1 |
| Gene Summary |
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017] |
| synonyms |
|
| Properties | |