8-oxoguanine DNA glycosylase ; Homo sapiens






731 Article(s)
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1 1495996 Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA. Proc Natl Acad Sci U S A 1992 Aug 1 1
2 9187114 Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. Cancer Res 1997 Jun 1 3
3 9197244 A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer. Curr Biol 1997 Jun 1 4
4 9223305 Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 1997 Jul 22 1
5 9331411 The critical active-site amine of the human 8-oxoguanine DNA glycosylase, hOgg1: direct identification, ablation and chemical reconstitution. Chem Biol 1997 Sep 14
6 9372850 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) DNA glycosylase and AP lyase activities of hOGG1 protein and their substrate specificity. Mutat Res 1997 Oct 22
7 9434942 Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage. Mamm Genome 1998 Jan 1
8 9582353 Characterization of a novel cis-syn and trans-syn-II pyrimidine dimer glycosylase/AP lyase from a eukaryotic algal virus, Paramecium bursaria chlorella virus-1. J Biol Chem 1998 May 22 1
9 9587483 [Repair of oxidized guanine in mammals: OGG1 genes]. C R Seances Soc Biol Fil 1997 1
10 9611236 Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage. Nucleic Acids Res 1998 Jun 15 2
11 9662341 Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours. Oncogene 1998 Jun 11 1
12 9681819 Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA. Oncogene 1998 Jun 25 8
13 9683192 Opposite base-dependent excision of 7,8-dihydro-8-oxoadenine by the Ogg1 protein of Saccharomyces cerevisiae. Carcinogenesis 1998 Jul 3
14 9765618 Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer. Jpn J Cancer Res 1998 Aug 3
15 9801308 The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation. Nucleic Acids Res 1998 Nov 15 5
16 9935223 New DNA polymorphisms of human MMH/OGG1 gene: prevalence of one polymorphism among lung-adenocarcinoma patients in Japanese. Int J Cancer 1999 Jan 5 8
17 9973627 Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome group B cells. Nucleic Acids Res 1999 Mar 1 1
18 10233168 Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs. Mol Biol Cell 1999 May 1
19 10329432 Human MMH (OGG1) type 1a protein is a major enzyme for repair of 8-hydroxyguanine lesions in human cells. Biochem Biophys Res Commun 1999 May 19 6
20 10329732 The type of DNA glycosylase determines the base excision repair pathway in mammalian cells. J Biol Chem 1999 May 21 4
21 10425451 Production and characterisation of deletion mutants of ovine growth hormone. J Mol Endocrinol 1999 Aug 1
22 10469635 Overexpression of Ogg1 in mammalian cells: effects on induced and spontaneous oxidative DNA damage and mutagenesis. Carcinogenesis 1999 Sep 2
23 10497264 Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations. Nucleic Acids Res 1999 Oct 15 14
24 10569802 Frequent allelic loss at chromosome 3p distinct from genetic alterations of the 8-oxoguanine DNA glycosylase 1 gene in head and neck cancer. Mol Carcinog 1999 Dec 1
25 10657953 The effect of hOGG1 and glutathione peroxidase I genotypes and 3p chromosomal loss on 8-hydroxydeoxyguanosine levels in lung cancer. Carcinogenesis 2000 Feb 3
26 10671534 Distinct repair activities of human 7,8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7,8-dihydro-8-oxoguanine. J Biol Chem 2000 Feb 18 7
27 10717238 Expression of the OGG1-type 1a (nuclear form) protein in cancerous and non-cancerous human cells. Int J Oncol 2000 Apr 1
28 10744126 hOGG1 Ser326Cys polymorphism and lung cancer susceptibility. Cancer Epidemiol Biomarkers Prev 1999 Aug 3
29 10775435 The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis. Arch Biochem Biophys 2000 May 1 5
30 10778969 Overexpression of the hOGG1 gene and high 8-hydroxy-2'-deoxyguanosine (8-OHdG) lyase activity in human colorectal carcinoma: regulation mechanism of the 8-OHdG level in DNA. Clin Cancer Res 2000 Apr 2
31 10908322 Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the Ogg1 protein. Nucleic Acids Res 2000 Jul 15 20
32 10982789 Enhanced mitochondrial DNA repair and cellular survival after oxidative stress by targeting the human 8-oxoguanine glycosylase repair enzyme to mitochondria. J Biol Chem 2000 Dec 1 2
33 11002420 Leukemic cell line, KG-1 has a functional loss of hOGG1 enzyme due to a point mutation and 8-hydroxydeoxyguanosine can kill KG-1. Oncogene 2000 Sep 14 2
34 11018584 Characterization of the hOGG1 promoter and its expression during the cell cycle. Mutat Res 2000 Oct 16 1
35 11093817 hOGG1 polymorphism and loss of heterozygosity (LOH): significance for lung cancer susceptibility in a caucasian population. Int J Cancer 2000 Dec 15 7
36 11097235 A preliminary evaluation of intra- and interindividual variations of hOGG1 messenger RNA levels in peripheral blood cells as determined by a real-time polymerase chain reaction technique. Cancer Epidemiol Biomarkers Prev 2000 Nov 2
37 11106507 Involvement of phylogenetically conserved acidic amino acid residues in catalysis by an oxidative DNA damage enzyme formamidopyrimidine glycosylase. Biochemistry 2000 Dec 12 1
38 11110971 [Genetic polymorphism in hOGG1 and susceptibility to esophageal cancer in Chinese]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2000 Dec 3
39 11139613 Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair. Nucleic Acids Res 2001 Jan 15 9
40 11170398 DNA synthesis and dRPase activities of polymerase beta are both essential for single-nucleotide patch base excision repair in mammalian cell extracts. Biochemistry 2001 Jan 23 1
41 11181447 Changes in DNA 8-hydroxyguanine levels, 8-hydroxyguanine repair activity, and hOGG1 and hMTH1 mRNA expression in human lung alveolar epithelial cells induced by crocidolite asbestos. Carcinogenesis 2001 Feb 1
42 11238994 Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity step. Nucleic Acids Res 2001 Mar 15 2
43 11246125 Cadmium adaptation in the lung - a double-edged sword? Toxicology 2001 Mar 7 1
44 11287425 Stimulation of human endonuclease III by Y box-binding protein 1 (DNA-binding protein B). Interaction between a base excision repair enzyme and a transcription factor. J Biol Chem 2001 Jun 15 3
45 11307145 Ser326Cys polymorphism in hOGG1 gene and risk of esophageal cancer in a Chinese population. Int J Cancer 2001 May 20 7
46 11356334 Enhancement of OGG1 protein AP lyase activity by increase of APEX protein. Mutat Res 2001 Jun 5 7
47 11369503 Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence. Free Radic Biol Med 2001 May 15 1
48 11431349 Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N,N',N"-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo. Cancer Res 2001 Jul 1 1
49 11459633 DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326. Mutat Res 2001 Aug 9 4
50 11522631 Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide. Cancer Res 2001 Sep 1 6