Protein Name endothelial PAS domain protein 1
Organism Homo sapiens
Gene ID 2034
Gene Symbol

EPAS1

UniProt Q99814 (EPAS1_HUMAN), B3KW07 (B3KW07_HUMAN)
Relationships Total Number of functionally related compound(s) : 257
Total Number of Articles : 456
Description

endothelial PAS domain protein 1

Gene Summary

This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009]

synonyms
  • endothelial PAS domain-containing protein 1
  • EPAS-1
  • HIF-1-alpha-like factor
Click to show/hide the synonyms
Properties