endothelial PAS domain protein 1 ; Homo sapiens






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1 9079689 Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem 1997 Mar 28 2
2 9808618 The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 1998 Nov 1 1
3 9890965 Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha. J Biol Chem 1999 Jan 22 2
4 10922063 Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci U S A 2000 Aug 1 1
5 11301389 Regulation of vascular endothelial growth factor transcription by endothelial PAS domain protein 1 (EPAS1) and possible involvement of EPAS1 in the angiogenesis of renal cell carcinoma. Cancer 2001 Apr 15 4
6 11336512 Human cytotrophoblast expression of the von Hippel-Lindau protein is downregulated during uterine invasion in situ and upregulated by hypoxia in vitro. Dev Biol 2001 May 15 3
7 11585776 Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway. Cancer Res 2001 Oct 1 1
8 11688986 Hypoxia-inducible factor 2alpha binds to cobalt in vitro. Biochem Biophys Res Commun 2001 Nov 9 9
9 11796494 Induction of vascular endothelial growth factor by IGF-I in osteoblast-like cells is mediated by the PI3K signaling pathway through the hypoxia-inducible factor-2alpha. Endocrinology 2002 Feb 1
10 11839666 Hypoxia-induced, perinecrotic expression of endothelial Per-ARNT-Sim domain protein-1/hypoxia-inducible factor-2alpha correlates with tumor progression, vascularization, and focal macrophage infiltration in bladder cancer. Clin Cancer Res 2002 Feb 2
11 11888900 Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer. Cancer Res 2002 Mar 1 3
12 11969369 Oxygen sensors and angiogenesis. Semin Cell Dev Biol 2002 Feb 1
13 12011461 Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. Proc Natl Acad Sci U S A 2002 May 14 1
14 12099714 Endothelial PAS domain protein 1 (EPAS1) induces adrenomedullin gene expression in cardiac myocytes: role of EPAS1 in an inflammatory response in cardiac myocytes. J Mol Cell Cardiol 2002 Jul 1
15 12186875 Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J Biol Chem 2002 Oct 18 7
16 12588875 MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300. J Biol Chem 2003 Apr 18 1
17 12606543 Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha. J Biol Chem 2003 May 2 2
18 14668441 Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor. Proc Natl Acad Sci U S A 2003 Dec 23 2
19 14767275 Prognostic significance of endothelial Per-Arnt-sim domain protein 1/hypoxia-inducible factor-2alpha expression in a subset of tumor associated macrophages in invasive bladder cancer. J Urol 2004 Mar 4
20 14966910 Expression of HIF-2alpha/EPAS1 in hepatocellular carcinoma. World J Gastroenterol 2004 Feb 15 2
21 15039136 The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells. Am J Respir Cell Mol Biol 2004 Aug 2
22 15192019 Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1. Circ Res 2004 Jul 23 1
23 15247232 Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem 2004 Sep 10 1
24 15613462 Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel-Lindau syndrome. Endocr Relat Cancer 2004 Dec 2
25 15653678 Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator. J Biol Chem 2005 Apr 8 1
26 15800931 Phenotypic persistence after reoxygenation of hypoxic neuroblastoma cells. Int J Cancer 2005 Aug 20 2
27 16054088 Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab 2005 Jun 1
28 16054089 Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab 2005 Jun 2
29 16627790 White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke 2006 Jun 1
30 16740701 Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection. Cancer Res 2006 Jun 1 1
31 16760477 Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. J Biol Chem 2006 Aug 11 3
32 16826581 The relation between hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression with anemia and outcome in surgically treated head and neck cancer. Cancer 2006 Aug 15 1
33 16924414 Targeting the hypoxia inducible factor pathway with mitochondrial uncouplers. Mol Cell Biochem 2007 Feb 1
34 16956952 Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. J Virol 2006 Nov 1
35 16971531 The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes. J Neurosci 2006 Sep 13 1
36 17024177 The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression. EMBO J 2006 Oct 18 1
37 17404509 Hypoxia inducible factor-2alpha in cancer. Cell Cycle 2007 Apr 15 2
38 17417656 Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat Struct Mol Biol 2007 May 6
39 17495954 Upregulation of hypoxia-inducible factors in normal and psoriatic skin. J Invest Dermatol 2007 Oct 1
40 17537234 Hypoxic conditions increase hypoxia-inducible transcription factor 2alpha and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients. Arthritis Res Ther 2007 1
41 17760870 Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation. J Neurochem 2007 Dec 1
42 17881647 Is congenital secondary erythrocytosis/polycythemia caused by activating mutations within the HIF-2 alpha iron-responsive element? Blood 2007 Oct 1 1
43 18055454 Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2. J Biol Chem 2008 Feb 8 1
44 18319549 Prognostic significance of HIF-2alpha expression on tumor infiltrating macrophages in patients with uterine cervical cancer undergoing radiotherapy. J Med Invest 2008 Feb 5
45 18378852 Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis. Blood 2008 Jun 1 1
46 18423372 Heterogeneity in binding and gene-expression regulation by HIF-2alpha. Biochem Biophys Res Commun 2008 Jun 27 1
47 18463234 Mitochondria, oxygen sensing, and the regulation of HIF-2alpha. Focus on "Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line". Am J Physiol Cell Physiol 2008 Jun 3
48 18515279 HIF and reactive oxygen species regulate oxidative phosphorylation in cancer. Carcinogenesis 2008 Aug 2
49 18544564 Hypoxia-inducible factor-2alpha regulates the expression of TRAIL receptor DR5 in renal cancer cells. Carcinogenesis 2008 Sep 3
50 18645007 Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha. Mol Cancer Ther 2008 Jul 1