1 | 9079689 | Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. | J Biol Chem | 1997 Mar 28 |
2 |
2 | 9808618 | The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. | Genes Dev | 1998 Nov 1 |
1 |
3 | 9890965 | Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha. | J Biol Chem | 1999 Jan 22 |
2 |
4 | 10922063 | Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. | Proc Natl Acad Sci U S A | 2000 Aug 1 |
1 |
5 | 11301389 | Regulation of vascular endothelial growth factor transcription by endothelial PAS domain protein 1 (EPAS1) and possible involvement of EPAS1 in the angiogenesis of renal cell carcinoma. | Cancer | 2001 Apr 15 |
4 |
6 | 11336512 | Human cytotrophoblast expression of the von Hippel-Lindau protein is downregulated during uterine invasion in situ and upregulated by hypoxia in vitro. | Dev Biol | 2001 May 15 |
3 |
7 | 11585776 | Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway. | Cancer Res | 2001 Oct 1 |
1 |
8 | 11688986 | Hypoxia-inducible factor 2alpha binds to cobalt in vitro. | Biochem Biophys Res Commun | 2001 Nov 9 |
9 |
9 | 11796494 | Induction of vascular endothelial growth factor by IGF-I in osteoblast-like cells is mediated by the PI3K signaling pathway through the hypoxia-inducible factor-2alpha. | Endocrinology | 2002 Feb |
1 |
10 | 11839666 | Hypoxia-induced, perinecrotic expression of endothelial Per-ARNT-Sim domain protein-1/hypoxia-inducible factor-2alpha correlates with tumor progression, vascularization, and focal macrophage infiltration in bladder cancer. | Clin Cancer Res | 2002 Feb |
2 |
11 | 11888900 | Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer. | Cancer Res | 2002 Mar 1 |
3 |
12 | 11969369 | Oxygen sensors and angiogenesis. | Semin Cell Dev Biol | 2002 Feb |
1 |
13 | 12011461 | Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. | Proc Natl Acad Sci U S A | 2002 May 14 |
1 |
14 | 12099714 | Endothelial PAS domain protein 1 (EPAS1) induces adrenomedullin gene expression in cardiac myocytes: role of EPAS1 in an inflammatory response in cardiac myocytes. | J Mol Cell Cardiol | 2002 Jul |
1 |
15 | 12186875 | Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. | J Biol Chem | 2002 Oct 18 |
7 |
16 | 12588875 | MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300. | J Biol Chem | 2003 Apr 18 |
1 |
17 | 12606543 | Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha. | J Biol Chem | 2003 May 2 |
2 |
18 | 14668441 | Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor. | Proc Natl Acad Sci U S A | 2003 Dec 23 |
2 |
19 | 14767275 | Prognostic significance of endothelial Per-Arnt-sim domain protein 1/hypoxia-inducible factor-2alpha expression in a subset of tumor associated macrophages in invasive bladder cancer. | J Urol | 2004 Mar |
4 |
20 | 14966910 | Expression of HIF-2alpha/EPAS1 in hepatocellular carcinoma. | World J Gastroenterol | 2004 Feb 15 |
2 |
21 | 15039136 | The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells. | Am J Respir Cell Mol Biol | 2004 Aug |
2 |
22 | 15192019 | Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1. | Circ Res | 2004 Jul 23 |
1 |
23 | 15247232 | Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. | J Biol Chem | 2004 Sep 10 |
1 |
24 | 15613462 | Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel-Lindau syndrome. | Endocr Relat Cancer | 2004 Dec |
2 |
25 | 15653678 | Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator. | J Biol Chem | 2005 Apr 8 |
1 |
26 | 15800931 | Phenotypic persistence after reoxygenation of hypoxic neuroblastoma cells. | Int J Cancer | 2005 Aug 20 |
2 |
27 | 16054088 | Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. | Cell Metab | 2005 Jun |
1 |
28 | 16054089 | Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. | Cell Metab | 2005 Jun |
2 |
29 | 16627790 | White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. | Stroke | 2006 Jun |
1 |
30 | 16740701 | Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection. | Cancer Res | 2006 Jun 1 |
1 |
31 | 16760477 | Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. | J Biol Chem | 2006 Aug 11 |
3 |
32 | 16826581 | The relation between hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression with anemia and outcome in surgically treated head and neck cancer. | Cancer | 2006 Aug 15 |
1 |
33 | 16924414 | Targeting the hypoxia inducible factor pathway with mitochondrial uncouplers. | Mol Cell Biochem | 2007 Feb |
1 |
34 | 16956952 | Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. | J Virol | 2006 Nov |
1 |
35 | 16971531 | The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes. | J Neurosci | 2006 Sep 13 |
1 |
36 | 17024177 | The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression. | EMBO J | 2006 Oct 18 |
1 |
37 | 17404509 | Hypoxia inducible factor-2alpha in cancer. | Cell Cycle | 2007 Apr 15 |
2 |
38 | 17417656 | Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. | Nat Struct Mol Biol | 2007 May |
6 |
39 | 17495954 | Upregulation of hypoxia-inducible factors in normal and psoriatic skin. | J Invest Dermatol | 2007 Oct |
1 |
40 | 17537234 | Hypoxic conditions increase hypoxia-inducible transcription factor 2alpha and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients. | Arthritis Res Ther | 2007 |
1 |
41 | 17760870 | Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation. | J Neurochem | 2007 Dec |
1 |
42 | 17881647 | Is congenital secondary erythrocytosis/polycythemia caused by activating mutations within the HIF-2 alpha iron-responsive element? | Blood | 2007 Oct 1 |
1 |
43 | 18055454 | Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2. | J Biol Chem | 2008 Feb 8 |
1 |
44 | 18319549 | Prognostic significance of HIF-2alpha expression on tumor infiltrating macrophages in patients with uterine cervical cancer undergoing radiotherapy. | J Med Invest | 2008 Feb |
5 |
45 | 18378852 | Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis. | Blood | 2008 Jun 1 |
1 |
46 | 18423372 | Heterogeneity in binding and gene-expression regulation by HIF-2alpha. | Biochem Biophys Res Commun | 2008 Jun 27 |
1 |
47 | 18463234 | Mitochondria, oxygen sensing, and the regulation of HIF-2alpha. Focus on "Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line". | Am J Physiol Cell Physiol | 2008 Jun |
3 |
48 | 18515279 | HIF and reactive oxygen species regulate oxidative phosphorylation in cancer. | Carcinogenesis | 2008 Aug |
2 |
49 | 18544564 | Hypoxia-inducible factor-2alpha regulates the expression of TRAIL receptor DR5 in renal cancer cells. | Carcinogenesis | 2008 Sep |
3 |
50 | 18645007 | Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha. | Mol Cancer Ther | 2008 Jul |
1 |