Protein Name nudix hydrolase 15
Organism Homo sapiens
Gene ID 55270
Gene Symbol


UniProt Q9NV35 (NUD15_HUMAN)
Relationships Total Number of functionally related compound(s) : 64
Total Number of Articles : 172

nudix hydrolase 15

Gene Summary

This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]

  • nucleotide triphosphate diphosphatase NUDT15
  • 8-oxo-dGTPase NUDT15
  • mutT homolog 2
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