| Protein Name | nudix hydrolase 15 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 55270 |
| Gene Symbol | NUDT15 |
| UniProt | Q9NV35 (NUD15_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
64
Total Number of Articles : 172 |
Description |
nudix hydrolase 15 |
| Gene Summary |
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016] |
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