nudix hydrolase 15 ; Homo sapiens






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1 19419956 Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. J Biol Chem 2009 Jul 17 4
2 20144704 Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5. Free Radic Biol Med 2010 May 1 5
3 22556419 Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. J Biol Chem 2012 Jun 15 7
4 25108385 A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia. Nat Genet 2014 Sep 3
5 25624441 Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia. J Clin Oncol 2015 Apr 10 1
6 26033531 Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia. Br J Haematol 2015 Oct 1
7 26067482 Update on thiopurine pharmacogenetics in inflammatory bowel disease. Pharmacogenomics 2015 Jul 1
8 26076924 NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD. Pharmacogenomics J 2016 Jun 2
9 26238318 Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2. Nat Commun 2015 Aug 4 2
10 26405151 NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia. Haematologica 2016 Jan 1
11 26503813 NUDT15 gene polymorphism related to mercaptopurine intolerance in Taiwan Chinese children with acute lymphoblastic leukemia. Pharmacogenomics J 2016 Nov 4
12 26590936 NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease. J Gastroenterol 2016 Jan 7
13 26735160 NUDT15 variant is the most common variant associated with thiopurine-induced early leukopenia and alopecia in Korean pediatric patients with Crohn's disease. Eur J Gastroenterol Hepatol 2016 Apr 5
14 26878724 NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity. Nat Genet 2016 Apr 7
15 26935390 Thiopurine Biotransformation and Pharmacological Effects: Contribution of Oxidative Stress. Curr Drug Metab 2016 2
16 27193222 Genotyping NUDT15 can predict the dose reduction of 6-MP for children with acute lymphoblastic leukemia especially at a preschool age. J Hum Genet 2016 Sep 2
17 27308664 NUDT15: a novel player in thiopurine metabolism. J Gastrointestin Liver Dis 2016 Jun 1
18 27381176 Further evidence that a variant of the gene NUDT15 may be an important predictor of azathioprine-induced toxicity in Chinese subjects: a case report. J Clin Pharm Ther 2016 Oct 5
19 27384855 Severe 6-mercaptopurine-induced hematotoxicity in childhood an ALL patient with homozygous NUDT15 missence variants. Rinsho Ketsueki 2016 Jun 9
20 27416873 Nucleoside diphosphate-linked moiety X-type motif 15 C415T variant as a predictor for thiopurine-induced toxicity in Indian patients. J Gastroenterol Hepatol 2017 Mar 5
21 27498738 Pharmacogenomics for leukemia treatment. Rinsho Ketsueki 2016 Jul 1
22 27530327 NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine. Cancer Res 2016 Sep 15 18
23 27577869 NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon. Pediatr Blood Cancer 2017 Jan 3
24 27604507 NUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease. Aliment Pharmacol Ther 2016 Nov 2
25 28088792 Impact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose. Oncotarget 2017 Feb 21 5
26 28146264 TPMT and NUDT15 genes are both related to mercaptopurine intolerance in acute lymphoblastic leukaemia patients from Uruguay. Br J Haematol 2018 Apr 1
27 28277331 NUDT15 genotype distributions in the Korean population. Pharmacogenet Genomics 2017 May 1
28 28418010 Interaction between NUDT15 and ABCC4 variants enhances intolerability of 6-mercaptopurine in Japanese patients with childhood acute lymphoblastic leukemia. Pharmacogenomics J 2018 Apr 1
29 28445187 The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia. Pharmacogenet Genomics 2017 Jun 1
30 28470355 Association of NUDT15 c.415C>T allele and thiopurine-induced leukocytopenia in Asians: a systematic review and meta-analysis. Ir J Med Sci 2018 Feb 6
31 28498350 Comparison of Direct Sequencing, Real-Time PCR-High Resolution Melt (PCR-HRM) and PCR-Restriction Fragment Length Polymorphism (PCR-RFLP) Analysis for Genotyping of Common Thiopurine Intolerant Variant Alleles NUDT15 c.415C>T and TPMT c.719A>G (TPMT*3C). Diagnostics (Basel) 2017 May 12 2
32 28566182 NUDT15 p.R139C variant is common and strongly associated with azathioprine-induced early leukopenia and severe alopecia in Korean patients with various neurological diseases. J Neurol Sci 2017 Jul 15 3
33 28570428 Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis. Inflamm Bowel Dis 2017 Sep 4
34 28659275 Novel variants in <i>NUDT15</i> and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry. Blood 2017 Sep 7 2
35 28670229 <i>NUDT15</i>, <i>FTO</i>, and <i>RUNX1</i> genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases. Intest Res 2017 Jul 3
36 28883280 Susceptibility to 6-mercaptopurine toxicity related with NUDT15 and ABCC4 variants in Japanese childhood acute lymphoblastic leukemia. Rinsho Ketsueki 2017 2
37 28903549 NUDT15 Variants Cause Hematopoietic Toxicity with Low 6-TGN Levels in Children with Acute Lymphoblastic Leukemia. Cancer Res Treat 2018 Jul 1
38 28963908 Emerging role of NUDT15 polymorphisms in 6-mercaptopurine metabolism and dose related toxicity in acute lymphoblastic leukaemia. Leuk Res 2017 Nov 2
39 29065511 Novel Tetra-Primer ARMS-PCR Assays for Thiopurine Intolerance Susceptibility Mutations NUDT15 c.415C&gt;T and TPMT c.719A&gt;G (TPMT*3C) in East Asians. Genes (Basel) 2017 Oct 23 2
40 29192347 Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping. J Gastroenterol 2018 Feb 13
41 29206869 Measurements of 6-thioguanine nucleotide levels with TPMT and NUDT15 genotyping in patients with Crohn's disease. PLoS One 2017 1
42 29210335 Predictive role of NUDT15 variants on thiopurine-induced myelotoxicity in Asian inflammatory bowel disease patients. Pharmacogenomics 2018 Jan 6
43 29285286 MutT-related proteins are novel progression and prognostic markers for colorectal cancer. Oncotarget 2017 Dec 1 1
44 29398872 Influence of <i>NUDT15</i> variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines. World J Gastroenterol 2018 Jan 28 5
45 29470173 Preemptive NUDT15 genotyping: redefining the management of patients with thiopurine-induced toxicity. Drug Metab Pers Ther 2018 Mar 28 10
46 29482072 The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome stability under oxidative stress. Mutat Res 2018 Mar 6
47 29491687 Comparison of <i>TPMT</i> and <i>NUDT15</i> polymorphisms in Chinese patients with inflammatory bowel disease. World J Gastroenterol 2018 Feb 28 4
48 29519865 Combination of common and novel rare <i>NUDT15</i> variants improves predictive sensitivity of thiopurine-induced leukopenia in children with acute lymphoblastic leukemia. Haematologica 2018 Jul 1
49 29702976 NUDT15 R139C variation increases the risk of azathioprine-induced toxicity in Chinese subjects: Case report and literature review. Medicine (Baltimore) 2018 Apr 4
50 29704867 Azathioprine-induced alopecia and leukopenia associated with NUDT15 polymorphisms. J Eur Acad Dermatol Venereol 2018 Oct 1