| Protein Name | ghrelin and obestatin prepropeptide |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 59301 |
| Gene Symbol | Ghrl |
| UniProt | Q9QYH7 (GHRL_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
507
Total Number of Articles : 775 |
Description |
ghrelin and obestatin prepropeptide |
| Gene Summary |
Enables ghrelin receptor binding activity and growth hormone-releasing hormone activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of peptide hormone secretion; and regulation of digestive system process. Acts upstream of or within negative regulation of insulin secretion. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study middle cerebral artery infarction. Biomarker of multiple endocrine neoplasia and obstructive sleep apnea. Human ortholog(s) of this gene implicated in diabetic neuropathy; esophagus adenocarcinoma; morbid obesity; obesity; and type 2 diabetes mellitus. Orthologous to human GHRL (ghrelin and obestatin prepropeptide). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |