Protein Name ghrelin and obestatin prepropeptide
Organism Rattus norvegicus
Gene ID 59301
Gene Symbol

Ghrl

UniProt Q9QYH7 (GHRL_RAT)
Relationships Total Number of functionally related compound(s) : 507
Total Number of Articles : 775
Description

ghrelin and obestatin prepropeptide

Gene Summary

Enables ghrelin receptor binding activity and growth hormone-releasing hormone activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of peptide hormone secretion; and regulation of digestive system process. Acts upstream of or within negative regulation of insulin secretion. Located in cytoplasm. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study middle cerebral artery infarction. Biomarker of multiple endocrine neoplasia and obstructive sleep apnea. Human ortholog(s) of this gene implicated in diabetic neuropathy; esophagus adenocarcinoma; morbid obesity; obesity; and type 2 diabetes mellitus. Orthologous to human GHRL (ghrelin and obestatin prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • appetite-regulating hormone
  • ghrelin/obestatin prepropeptide
  • growth hormone secretagogue
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Properties