Protein Name hypoxia inducible factor 1, alpha subunit
Organism Mus musculus
Gene ID 15251
Gene Symbol


UniProt Q61221 (HIF1A_MOUSE), A0A0R4J1E9 (A0A0R4J1E9_MOUSE), Q3UCW2 (Q3UCW2_MOUSE)
Relationships Total Number of functionally related compound(s) : 724
Total Number of Articles : 1412

hypoxia inducible factor 1, alpha subunit

Gene Summary

This gene encodes the alpha subunit which, along with the beta subunit, forms a heterodimeric transcription factor that regulates the cellular and developmental response to reduced oxygen tension. The transcription factor has been shown to regulate genes involved in several biological processes, including erythropoiesis and angiogenesis which aid in increased delivery of oxygen to hypoxic regions. The transcription factor also plays a role in the induction of genes involved in cell proliferation and survival, energy metabolism, apoptosis, and glucose and iron metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

  • hypoxia-inducible factor 1-alpha
  • ARNT-interacting protein
  • HIF-1-alpha
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