hypoxia inducible factor 1, alpha subunit ; Mus musculus






1412 Article(s)
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1 8662957 The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells. J Biol Chem 1996 Jun 21 2
2 9027741 Oxygen- and dioxin-regulated gene expression in mouse hepatoma cells. Kidney Int 1997 Feb 1
3 9121557 Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 1997 Mar 27 1
4 9278421 Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 1997 Sep 5 1
5 9368100 Molecular characterization of the murine Hif-1 alpha locus. Gene Expr 1997 13
6 9406238 Hypoxia response elements. Oncol Res 1997 1
7 9558407 Mouse hypoxia-inducible factor-1alpha is encoded by two different mRNA isoforms: expression from a tissue-specific and a housekeeping-type promoter. Blood 1998 May 1 1
8 9606183 HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 1998 Jun 1 2
9 9888442 Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression. Invest Ophthalmol Vis Sci 1999 Jan 1
10 10074486 Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J Clin Invest 1999 Mar 1
11 10630574 Differential gene expression in wild-type and arnt-defective mouse hepatoma (Hepa1c1c7) cells. Toxicol Sci 1999 Dec 3
12 10865838 Signaling angiogenesis via p42/p44 MAP kinase cascade. Ann N Y Acad Sci 2000 May 2
13 10961998 The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia. J Biol Chem 2000 Nov 17 1
14 11043581 Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha. Mol Endocrinol 2000 Oct 1
15 11191053 MAP kinases and hypoxia in the control of VEGF expression. Cancer Metastasis Rev 2000 2
16 11356821 Selected Contribution: Osteocytes upregulate HIF-1alpha in response to acute disuse and oxygen deprivation. J Appl Physiol (1985) 2001 Jun 4
17 11381139 Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt. Proc Natl Acad Sci U S A 2001 Jun 5 1
18 11404263 Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia. Am J Physiol Lung Cell Mol Physiol 2001 Jul 3
19 11606368 Hypoxia-inducible factor-1alpha is an intrinsic marker for hypoxia in cervical cancer xenografts. Cancer Res 2001 Oct 15 2
20 11698256 HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha. Am J Physiol Cell Physiol 2001 Dec 1
21 11726537 Hypoxia affects expression of circadian genes PER1 and CLOCK in mouse brain. FASEB J 2001 Dec 2
22 11792862 Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proc Natl Acad Sci U S A 2002 Jan 22 1
23 11909946 The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent. Mol Cell Biol 2002 Apr 1
24 11929818 Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells. Cancer Res 2002 Apr 1 1
25 12006670 Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol Biol Cell 2002 May 1
26 12019179 Rescue of hypoxia-inducible factor-1alpha-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor. Cancer Res 2002 May 15 1
27 12133832 Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation. Identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein. J Biol Chem 2002 Oct 11 2
28 12242109 The role of iron in cell cycle progression and the proliferation of neoplastic cells. Biochim Biophys Acta 2002 Oct 2 5
29 12370277 Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest 2002 Oct 1
30 12468553 Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product. J Biol Chem 2003 Feb 28 3
31 12479793 Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation. Biochem J 2003 Mar 15 4
32 12482866 Expression of hypoxia-inducible factors in the peri-implantation mouse uterus is regulated in a cell-specific and ovarian steroid hormone-dependent manner. Evidence for differential function of HIFs during early pregnancy. J Biol Chem 2003 Feb 28 1
33 12594177 The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis. FASEB J 2003 Apr 5
34 12620994 HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. Development 2003 Apr 1
35 12628185 HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 2003 Mar 7 2
36 12651620 Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol 2003 Apr 1
37 12657718 The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation. Mol Cancer Ther 2003 Mar 1
38 12761491 The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene 2003 May 22 2
39 12832481 Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol 2003 Jul 2
40 14580376 Oxygen-regulated expression of TGF-beta 3, a growth factor involved in trophoblast differentiation. Placenta 2003 Nov 1
41 14615418 The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies. Lab Invest 2003 Nov 5
42 14645546 Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 2003 Dec 1
43 14707731 Increased expression of hypoxia-inducible factor-1alpha, p48, and the Notch signaling cascade during acute pancreatitis in mice. Pancreas 2004 Jan 2
44 14981066 Protection from ischemic heart injury by a vigilant heme oxygenase-1 plasmid system. Hypertension 2004 Apr 1
45 15024078 Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1alpha expression. Mol Cell Biol 2004 Apr 1
46 15026543 Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol Cancer Ther 2004 Mar 1
47 15067333 Quinoxaline 1,4-dioxides are novel angiogenesis inhibitors that potentiate antitumor effects of ionizing radiation. Int J Oncol 2004 May 2
48 15094311 Nickel-induced 1,4-alpha-glucan branching enzyme 1 up-regulation via the hypoxic signaling pathway. Toxicol Appl Pharmacol 2004 May 1 10
49 15121835 Glucose utilization is essential for hypoxia-inducible factor 1 alpha-dependent phosphorylation of c-Jun. Mol Cell Biol 2004 May 6
50 15132980 Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart. FASEB J 2004 Jul 4