| Protein Name | UPF1 RNA helicase and ATPase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5976 |
| Gene Symbol | UPF1 |
| UniProt | Q92900 (RENT1_HUMAN), A0A024R7L8 (A0A024R7L8_HUMAN), A0A024R7L5 (A0A024R7L5_HUMAN), B3KY55 (B3KY55_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
65
Total Number of Articles : 80 |
Description |
UPF1 RNA helicase and ATPase |
| Gene Summary |
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
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| Properties | |