cytochrome P450 family 1 subfamily A member 2 ; Homo sapiens






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1 134910 2,3,7,8-Tetrachlorodibenzo-p-dioxin: environmental contaminant and molecular probe. Fed Proc 1976 Oct 5
2 697921 Ellipticines as potent inhibitors of aryl hydrocarbon hydroxylase: their binding to microsomal cytochromes P450 and protective effect against benzo(a)pyrene mutagenicity. Biochem Pharmacol 1978 2
3 711851 Human skin aryl hydrocarbon hydroxylase. Induction by coal tar. J Clin Invest 1978 Nov 3
4 1026852 The effect of cigarette smoke on aryl hydrocarbon hydroxylase activity and cytochrome P450 content in rat liver and lung microsomes. Oncology 1976 1
5 1302044 Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1. Pharmacogenetics 1992 Apr 11
6 1306111 Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites. Pharmacogenetics 1992 Jun 6
7 1306118 Caffeine as a probe for human cytochromes P450: validation using cDNA-expression, immunoinhibition and microsomal kinetic and inhibitor techniques. Pharmacogenetics 1992 Aug 2
8 1394840 Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine. Carcinogenesis 1992 Sep 4
9 1426869 Induction of cytochrome P450IA genes (CYP1A) by omeprazole in the human alimentary tract. Gastroenterology 1992 Nov 1
10 1438044 Enzyme activities in the term human placenta: in vitro effect of cadmium. Pharmacol Toxicol 1992 Sep 1
11 1446722 Genetically engineered V79 Chinese hamster cells for stable expression of human cytochrome P450IA2. Eur J Pharmacol 1992 Sep 1 1
12 1473228 N-hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver. Carcinogenesis 1992 Dec 4
13 1490825 Dose dependent induction of CYP1A2 activity by omeprazole (Antra). Int J Clin Pharmacol Ther Toxicol 1992 Nov 2
14 1505152 Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin. Clin Pharmacol Ther 1992 Aug 2
15 1516612 Verapamil and drug metabolism by the cytochrome P450 isoform CYP1A2. Eur J Clin Pharmacol 1992 1
16 1536570 17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA. Arch Biochem Biophys 1992 Mar 1
17 1540958 Determinants of polycyclic aromatic hydrocarbon-DNA adducts in human placenta. Cancer Res 1992 Mar 15 4
18 1650214 Ah receptor mediating induction of cytochrome P450IA1 in a novel continuous human liver cell line (Mz-Hep-1). Detection by binding with [3H]2,3,7,8-tetrachlorodibenzo-p-dioxin and relationship to the activity of aryl hydrocarbon hydroxylase. Biochem Pharmacol 1991 Jul 15 1
19 1654865 Detection and characterization of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the human colon adenocarcinoma cell line LS180. Arch Biochem Biophys 1991 Oct 20
20 1793807 A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing. Chem Res Toxicol 1991 Sep-Oct 1
21 1800893 The use of genetically engineered V79 Chinese hamster cultures expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus assays. Mutagenesis 1991 Nov 3
22 1844873 Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin. Pharmacogenetics 1991 Nov 1
23 1846074 The Ah receptor, cytochrome P450IA1 mRNA induction, and aryl hydrocarbon hydroxylase in a human lymphoblastoid cell line. Biochem Pharmacol 1991 Jan 1 3
24 1909194 Modulation of erythropoiesis by novel human bone marrow cytochrome P450-dependent metabolites of arachidonic acid. Blood 1991 Sep 15 1
25 1934864 Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities. Clin Pharmacol Ther 1991 Nov 3
26 1946176 In vitro effect of mercury on aryl hydrocarbon hydroxylase, quinone reductase, catecholamine-O-methyltransferase and glucose-6-phosphate dehydrogenase activities in term human placenta. Pharmacol Toxicol 1991 May 2
27 2154949 Characterization of the Ah receptor mediating aryl hydrocarbon hydroxylase induction in the human liver cell line Hep G2. Arch Biochem Biophys 1990 Feb 1 9
28 2155194 Culture of human hepatocytes from small surgical liver biopsies. Biochemical characterization and comparison with in vivo. In Vitro Cell Dev Biol 1990 Jan 1
29 2217402 Preferential activation and genotoxicity of food derived heterocyclic amine mutagens by recombinant cytochrome P4501A2. Prog Clin Biol Res 1990 1
30 2262908 Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s. J Pharmacol Exp Ther 1990 Dec 3
31 2322313 Effect of xenobiotics on monooxygenase activities in cultured human hepatocytes. Biochem Pharmacol 1990 Apr 15 5
32 2351129 Influence of some anti-inflammatory drugs on the activity of aryl hydrocarbon hydroxylase and the cytochrome P450 content. Environ Res 1990 Jun 3
33 2395886 2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an extensive alteration of 17 beta-estradiol metabolism in MCF-7 breast tumor cells. Proc Natl Acad Sci U S A 1990 Sep 1
34 2464754 Relation between cytochrome P450IA1 expression and estrogen receptor content of human breast cancer cells. Mol Endocrinol 1989 Jan 2
35 2545344 Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor. Cancer Res 1989 Aug 15 6
36 2655891 Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002. Cancer Res 1989 Jun 15 2
37 2744682 [Effects of dioxin congeners on aryl hydrocarbon hydroxylase activity]. Fukuoka Igaku Zasshi 1989 May 5
38 2747632 The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene. Mol Pharmacol 1989 Jul 4
39 2785364 Studies on the interactions of MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) with the cytochrome P-450 enzyme system--clues to a possible aetiological factor in Parkinson's disease. Ann Acad Med Singap 1989 Jan 3
40 2833345 Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line. Cancer Res 1988 May 1 10
41 2834196 Placental markers of human exposure to polychlorinated biphenyls and polychlorinated dibenzofurans. Environ Health Perspect 1987 Dec 1
42 2901468 Theophylline metabolism by human, rabbit and rat liver microsomes and by purified forms of cytochrome P450. J Pharm Pharmacol 1988 Jun 4
43 2911085 Selective mutagenic activation by cytochrome P3-450 of carcinogenic arylamines found in foods. J Natl Cancer Inst 1989 Feb 1 1
44 3011254 Ah receptor mediating induction of aryl hydrocarbon hydroxylase: detection in human lung by binding of 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin. Cancer Res 1986 Jul 8
45 3032186 Vitamins E and K induce aryl hydrocarbon hydroxylase activity in human cell cultures. Biochem Biophys Res Commun 1987 Mar 30 1
46 3040233 Ah receptor in human placenta: stabilization by molybdate and characterization of binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, and benzo(a)pyrene. Cancer Res 1987 Sep 15 2
47 3114357 Dose requirements, assay procedures and tissue specificity for PCB inductation of P-450 dependent mono-oxygenase activity in the rat: implications for design of studies measuring in vivo induction of human placental mono-oxygenases. J Appl Toxicol 1987 Apr 2
48 3137222 Cytochrome P3-450 cDNA encodes aflatoxin B1-4-hydroxylase. J Biol Chem 1988 Sep 5 1
49 3143724 Altered regulation of P-450IA1 expression in a multidrug-resistant MCF-7 human breast cancer cell line. J Biol Chem 1988 Dec 15 4
50 3413034 Inhibitor panel studies of human hepatic and placental cytochrome P-450-associated monooxygenase activities. Pharmacol Toxicol 1988 May 7