| Protein Name | apoptosis-inducing factor, mitochondrion-associated 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 26926 |
| Gene Symbol | Aifm1 |
| UniProt | Q9Z0X1 (AIFM1_MOUSE), B1AU25 (B1AU25_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
108
Total Number of Articles : 107 |
Description |
apoptosis-inducing factor, mitochondrion-associated 1 |
| Gene Summary |
Enables several functions, including FAD binding activity; NAD(P)H oxidase H2O2-forming activity; and poly-ADP-D-ribose binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of necroptotic process; and protein import into mitochondrial intermembrane space. Acts upstream of or within neuron apoptotic process and regulation of apoptotic DNA fragmentation. Located in cytosol and mitochondrion. Is active in nucleus. Is expressed in several structures, including cerebral cortex; early embryo; long bone epiphyseal plate; retina; and submandibular gland primordium epithelium. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1). [provided by Alliance of Genome Resources, Jul 2025] |
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