| Protein Name | DNA polymerase kappa |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 51426 |
| Gene Symbol | POLK |
| UniProt | Q9UBT6 (POLK_HUMAN), A0A024RAP4 (A0A024RAP4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
47
Total Number of Articles : 41 |
Description |
DNA polymerase kappa |
| Gene Summary |
This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients. [provided by RefSeq, Sep 2016] |
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