| Protein Name | interleukin-1 receptor-associated kinase 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 16179 |
| Gene Symbol | Irak1 |
| UniProt | Q62406 (IRAK1_MOUSE), Q8BR10 (Q8BR10_MOUSE), B1AUW6 (B1AUW6_MOUSE), Q540G0 (Q540G0_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
86
Total Number of Articles : 85 |
Description |
interleukin-1 receptor-associated kinase 1 |
| Gene Summary |
Enables interleukin-1 receptor binding activity and protein kinase activity. Involved in negative regulation of cholesterol efflux; negative regulation of transcription, DNA-templated; and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including interleukin-1-mediated signaling pathway; response to molecule of bacterial origin; and toll-like receptor signaling pathway. Located in lipid droplet and membrane. Part of protein-containing complex. Is expressed in several structures, including liver; skeletal muscle; and urinary system. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022] |
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