interleukin-1 receptor-associated kinase 1 ; Mus musculus






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1 6661236 Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin. Biochem Biophys Res Commun 1983 Dec 16 2
2 6704949 Stimulation of alkaline phosphatase activity in mouse epidermis by tumor promoters. Cancer Lett 1984 Mar 1
3 6828143 Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane. Nature 1983 Feb 17-23 8
4 11062014 Tolerance and sensitization to endotoxin in Kupffer cells caused by acute ethanol involve interleukin-1 receptor-associated kinase. Biochem Biophys Res Commun 2000 Nov 2 6
5 11201166 [In vitro and in vivo study of regulation mechanisms of type I interleukin-1 receptor]. Yakugaku Zasshi 2001 Jan 6
6 11401982 Activation of interleukin-1 receptor-associated kinase by gram-negative flagellin. Infect Immun 2001 Jul 1
7 12096038 A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways. Int Immunol 2002 Jul 1
8 12865424 Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. J Biol Chem 2003 Sep 26 2
9 12867418 Ras participates in CpG oligodeoxynucleotide signaling through association with toll-like receptor 9 and promotion of interleukin-1 receptor-associated kinase/tumor necrosis factor receptor-associated factor 6 complex formation in macrophages. J Biol Chem 2003 Sep 19 1
10 14639920 [Ethanol changes sensitivity of Kupffer cells to endotoxin]. Nihon Arukoru Yakubutsu Igakkai Zasshi 2003 Oct 2
11 15829295 Differential induction of apoptosis by LPS and taxol in monocytic cells. Mol Immunol 2005 May 2
12 15849359 Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance. J Biol Chem 2005 Jun 17 3
13 15896296 Ethanol alters cellular activation and CD14 partitioning in lipid rafts. Biochem Biophys Res Commun 2005 Jun 24 1
14 16046709 Curcumin blocks interleukin-1 (IL-1) signaling by inhibiting the recruitment of the IL-1 receptor-associated kinase IRAK in murine thymoma EL-4 cells. J Nutr 2005 Aug 14
15 16385231 Ethanol-induced sensitization to endotoxin in Kupffer cells is dependent upon oxidative stress. Alcohol Clin Exp Res 2005 Dec 9
16 17548806 Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound. J Leukoc Biol 2007 Oct 1
17 18061674 Lipid rafts regulate ethanol-induced activation of TLR4 signaling in murine macrophages. Mol Immunol 2008 Apr 1
18 19540456 Gender dependent importance of IRAK-1 in dextran sulfate sodium induced colitis. Cell Immunol 2009 3
19 19850916 IRAK-1 contributes to lipopolysaccharide-induced reactive oxygen species generation in macrophages by inducing NOX-1 transcription and Rac1 activation and suppressing the expression of antioxidative enzymes. J Biol Chem 2009 Dec 18 9
20 20350813 Disaccharide derived from chondroitin sulfate A suppressed CpG-induced IL-6 secretion in macrophage-like J774.1 cells. Cytokine 2010 Jul 2
21 20450885 TLR4-mediated activation of mouse macrophages by Korean mistletoe lectin-C (KML-C). Biochem Biophys Res Commun 2010 Jun 4 2
22 21145320 Tick saliva regulates migration, phagocytosis, and gene expression in the macrophage-like cell line, IC-21. Exp Parasitol 2011 Mar 2
23 21198552 Kalopanaxsaponin A ameliorates experimental colitis in mice by inhibiting IRAK-1 activation in the NF-κB and MAPK pathways. Br J Pharmacol 2011 Apr 1
24 21295571 Lipopolysaccharide inhibits transforming growth factor-beta1-stimulated Smad6 expression by inducing phosphorylation of the linker region of Smad3 through a TLR4-IRAK1-ERK1/2 pathway. FEBS Lett 2011 Mar 9 2
25 21600888 Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation--the key step of inflammation. Biochem Pharmacol 2011 Aug 1 1
26 22364946 Reduced oxidative tissue damage during endotoxemia in IRAK-1 deficient mice. Mol Immunol 2012 Apr 1
27 22661083 Vasoactive intestinal peptide downregulates proinflammatory TLRs while upregulating anti-inflammatory TLRs in the infected cornea. J Immunol 2012 Jul 1 1
28 22849695 Ginsenoside Re ameliorates inflammation by inhibiting the binding of lipopolysaccharide to TLR4 on macrophages. J Agric Food Chem 2012 Sep 26 1
29 22868051 Histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates Toll-like receptor 4 signaling in lipopolysaccharide-stimulated mouse macrophages. J Surg Res 2012 Dec 3
30 22940243 Methanol extract of Osbeckia stellata suppresses lipopolysaccharide- and HCl/ethanol-induced inflammatory responses by inhibiting Src/Syk and IRAK1. J Ethnopharmacol 2012 Oct 11 5
31 23055935 Rhinovirus attenuates non-typeable Hemophilus influenzae-stimulated IL-8 responses via TLR2-dependent degradation of IRAK-1. PLoS Pathog 2012 3
32 23143987 MicroRNA-146a-mediated downregulation of IRAK1 protects mouse and human small intestine against ischemia/reperfusion injury. EMBO Mol Med 2012 Dec 1
33 23295168 In vitro and in vivo anti-inflammatory effect of Rhodomyrtus tomentosa methanol extract. J Ethnopharmacol 2013 Mar 7 2
34 23735482 Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells. Immunobiology 2013 Dec 1
35 23941302 Penta-O-galloyl-β-D-glucose ameliorates inflammation by inhibiting MyD88/NF-κB and MyD88/MAPK signalling pathways. Br J Pharmacol 2013 Nov 1
36 24316060 The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy. Neuroscience 2014 Feb 14 1
37 24379523 IRAK1/4-targeted anti-inflammatory action of caffeic acid. Mediators Inflamm 2013 1
38 24972244 Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-κB and MAPK pathways. Eur J Pharmacol 2014 Oct 5 7
39 25127755 ZnO nanoparticles induced adjuvant effect via toll-like receptors and Src signaling in Balb/c mice. Toxicol Lett 2014 Nov 4 2
40 25213465 Ursolic acid isolated from the seed of Cornus officinalis ameliorates colitis in mice by inhibiting the binding of lipopolysaccharide to Toll-like receptor 4 on macrophages. J Agric Food Chem 2014 Oct 8 1
41 25276218 The Rhizome Mixture of Anemarrhena asphodeloides and Coptidis chinensis Ameliorates Acute and Chronic Colitis in Mice by Inhibiting the Binding of Lipopolysaccharide to TLR4 and IRAK1 Phosphorylation. Evid Based Complement Alternat Med 2014 1
42 25325613 Protective effects of lupeol against D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure in mice. J Nat Prod 2014 Nov 26 1
43 25698557 Timosaponin AIII and its metabolite sarsasapogenin ameliorate colitis in mice by inhibiting NF-κB and MAPK activation and restoring Th17/Treg cell balance. Int Immunopharmacol 2015 Apr 1
44 26457732 STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma. J Clin Invest 2015 Nov 2 1
45 26593910 Brazilein Suppresses Inflammation through Inactivation of IRAK4-NF-κB Pathway in LPS-Induced Raw264.7 Macrophage Cells. Int J Mol Sci 2015 Nov 18 1
46 26615974 Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages. BMB Rep 2016 May 1
47 27135544 Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway. Int Immunopharmacol 2016 Jul 3
48 27664853 IinQ attenuates systemic inflammatory responses via selectively impairing the Myddosome complex formation upon TLR4 ligation. Biochem Pharmacol 2016 Dec 1 5
49 28213090 Glycyrrhetinic acid attenuates lipopolysaccharide-induced fulminant hepatic failure in d-galactosamine-sensitized mice by up-regulating expression of interleukin-1 receptor-associated kinase-M. Toxicol Appl Pharmacol 2017 Apr 1 1
50 28216638 Thymoquinone: An IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities. Sci Rep 2017 Feb 20 4