Protein Name ATP-binding cassette, sub-family B member 1B
Organism Mus musculus
Gene ID 18669
Gene Symbol


UniProt P06795 (MDR1B_MOUSE), B2RUR3 (B2RUR3_MOUSE)
Relationships Total Number of functionally related compound(s) : 469
Total Number of Articles : 500

ATP-binding cassette, sub-family B member 1B

Gene Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene encodes a membrane glycoprotein which confers a multidrug-resistance phenotype. The protein encoded by the human gene is an ATP-dependent drug efflux pump for xenobiotic compounds which is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to anticancer drugs. [provided by RefSeq, Jul 2008]

  • ATP-dependent translocase ABCB1
  • ATP-binding cassette sub-family B member 1
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B
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