Protein Name paraoxonase 1
Organism Homo sapiens
Gene ID 5444
Gene Symbol


UniProt P27169 (PON1_HUMAN)
Relationships Total Number of functionally related compound(s) : 761
Total Number of Articles : 1242

paraoxonase 1

Gene Summary

This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7. [provided by RefSeq, Aug 2017]

  • serum paraoxonase/arylesterase 1
  • A-esterase 1
  • K-45
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