lactate dehydrogenase B ; Homo sapiens






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1 1587525 Molecular characterization of genetic mutations in human lactate dehydrogenase (LDH) B (H) variant. Hum Genet 1992 May 1
2 2334429 A missense mutation found in human lactate dehydrogenase-B (H) variant gene. Biochem Biophys Res Commun 1990 Apr 30 2
3 3435492 The cDNA and protein sequences of human lactate dehydrogenase B. Biochem J 1987 Dec 15 1
4 5647843 Lactate dehydrogenase isozymes in parthenogenetic teiid lizards (Cnemidophorus). Science 1968 May 31 1
5 6411649 Lactate dehydrogenase A-subunit and B-subunit deficiencies: comparison of the physiological roles of LDH isozymes. Isozymes Curr Top Biol Med Res 1983 1
6 7248278 Selective inactivation of lactate dehydrogenase isoenzymes with ionic surfactants. Biochemistry 1981 May 26 1
7 9066679 Expression of proteins correlated with the unique cisplatin-sensitivity of testicular cancer. Anticancer Res 1997 Jan-Feb 1
8 9748363 Selective inhibitors of human lactate dehydrogenases and lactate dehydrogenase from the malarial parasite Plasmodium falciparum. J Med Chem 1998 Sep 24 3
9 11509017 A novel missense mutation in human lactate dehydrogenase B-subunit gene. Mol Genet Metab 2001 Aug 5
10 15347626 Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome. J Appl Physiol (1985) 2005 Jan 1
11 16193382 Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines. J Neurooncol 2005 Sep 1
12 16198644 A preliminary account of the properties of recombinant human Glyoxylate reductase (GRHPR), LDHA and LDHB with glyoxylate, and their potential roles in its metabolism. Biochim Biophys Acta 2005 Dec 1 7
13 16547507 Lactate dehydrogenase-B is silenced by promoter hypermethylation in human prostate cancer. Oncogene 2006 May 11 1
14 18789002 Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3. Biochem J 2009 Jan 1 1
15 18814027 Endothelial cell-laminin interaction: modulation of LDH expression involves alpha6beta4 integrin-FAK-p38MAPK pathway. Glycoconj J 2009 Aug 1
16 18978174 Laser microdissection expression profiling of marginal edges of colorectal tumours reveals evidence of increased lactate metabolism in the aggressive phenotype. Gut 2009 Mar 1
17 21332213 Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells. J Med Chem 2011 Mar 24 1
18 21356207 Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects. Exp Cell Res 2011 May 1 2
19 22027740 Loss of lactate dehydrogenase B subunit expression is correlated with tumour progression and independently predicts inferior disease-specific survival in urinary bladder urothelial carcinoma. Pathology 2011 Dec 2
20 22052811 Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase. ChemMedChem 2012 Feb 6 1
21 23139210 An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer. Cancer Res 2012 Nov 15 1
22 23281225 Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of resistance to antiepidermal growth factor receptor antibody. Proteomics 2013 Mar 2
23 23437403 Lactate dehydrogenase-B is silenced by promoter methylation in a high frequency of human breast cancers. PLoS One 2013 1
24 24280423 Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells. Cancer Metab 2013 Sep 6 1
25 24639007 NMR-based evaluation of the metabolic profile and response to dichloroacetate of human prostate cancer cells. NMR Biomed 2014 May 1
26 24643264 Analysis of the mitochondrial proteome of cybrid cells harbouring a truncative mitochondrial DNA mutation in respiratory complex I. Mol Biosyst 2014 Jun 2
27 25340584 Ribosomal readthrough at a short UGA stop codon context triggers dual localization of metabolic enzymes in Fungi and animals. PLoS Genet 2014 Oct 2
28 25620379 The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B. Mol Carcinog 2016 Jan 1
29 25807933 Suppressed expression of LDHB promotes pancreatic cancer progression via inducing glycolytic phenotype. Med Oncol 2015 May 4
30 25973606 Lactate dehydrogenase B is associated with the response to neoadjuvant chemotherapy in oral squamous cell carcinoma. PLoS One 2015 9
31 26032856 Inhibition of stress mediated cell death by human lactate dehydrogenase B in yeast. FEMS Yeast Res 2015 Aug 2
32 26126931 Yeast cell-based analysis of human lactate dehydrogenase isoforms. J Biochem 2015 Dec 2
33 26657874 LDHB and FABP4 are Associated With Progression and Poor Prognosis of Pancreatic Ductal Adenocarcinomas. Appl Immunohistochem Mol Morphol 2017 May/Jun 1
34 27294003 Cisplatin suppresses the growth and proliferation of breast and cervical cancer cell lines by inhibiting integrin β5-mediated glycolysis. Am J Cancer Res 2016 2
35 27622334 Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer. Cancer Cell 2016 Sep 12 7
36 27738103 Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle. J Biol Chem 2016 Dec 2 1
37 27904684 LDHB may be a significant predictor of poor prognosis in osteosarcoma. Am J Transl Res 2016 1
38 28106079 Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage. Sci Rep 2017 Jan 20 1
39 28404377 H<sub>2</sub>S-induced S-sulfhydration of lactate dehydrogenase a (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells. Biochem Pharmacol 2017 Jul 15 1
40 28536031 Lactate induces osteoblast differentiation by stabilization of HIF1α. Mol Cell Endocrinol 2017 Sep 5 1
41 28582845 Elevated lactate dehydrogenase (LDH) can be a marker of immune suppression in cancer: Interplay between hematologic and solid neoplastic clones and their microenvironments. Cancer Biomark 2017 Jul 4 4
42 28846077 Metabolic cooperation between co-cultured lung cancer cells and lung fibroblasts. Lab Invest 2017 Nov 1
43 29721424 NIR-Triggered Crystal Phase Transformation of NiTi-Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy. Adv Sci (Weinh) 2018 Apr 5
44 30443978 SIRT5-mediated deacetylation of LDHB promotes autophagy and tumorigenesis in colorectal cancer. Mol Oncol 2019 Feb 12
45 30923124 Lactic acidosis caused by repressed lactate dehydrogenase subunit B expression down-regulates mitochondrial oxidative phosphorylation via the pyruvate dehydrogenase (PDH)-PDH kinase axis. J Biol Chem 2019 May 10 2
46 31035592 Unappreciated Role of LDHA and LDHB to Control Apoptosis and Autophagy in Tumor Cells. Int J Mol Sci 2019 Apr 27 9
47 31086659 Characterization of the molecular changes associated with the overexpression of a novel epithelial cadherin splice variant mRNA in a breast cancer model using proteomics and bioinformatics approaches: identification of changes in cell metabolism and an increased expression of lactate dehydrogenase B. Cancer Metab 2019 1
48 31558821 Quantitative proteomic analysis of enhanced cellular effects of electrochemotherapy with Cisplatin in triple-negative breast cancer cells. Sci Rep 2019 Sep 26 1
49 31660843 Evaluation of Tissue and Serum Expression Levels of Lactate Dehydrogenase Isoenzymes in Patients with Head and Neck Squamous Cell Carcinoma. Anticancer Agents Med Chem 2019 1
50 31804482 Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect. Nat Commun 2019 Dec 5 16