| Protein Name | lactate dehydrogenase B |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3945 |
| Gene Symbol | LDHB |
| UniProt | P07195 (LDHB_HUMAN), Q5U077 (Q5U077_HUMAN), A0A5F9ZHM4 (A0A5F9ZHM4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
71
Total Number of Articles : 77 |
Description |
lactate dehydrogenase B |
| Gene Summary |
This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016] |
| synonyms |
|
| Properties | |