glutamine fructose-6-phosphate transaminase 1 ; Rattus norvegicus






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1 2037571 Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation. J Biol Chem 1991 Jun 5 19
2 2938667 Short- and long-term consequences of intracranial injections of the excitotoxin, quinolinic acid, as evidenced by GFA immunohistochemistry of astrocytes. Brain Res 1986 Apr 23 1
3 3125057 Sustained seizures cause circumscribed cerebral changes in glial fibrillary acidic protein, neurofilament and laminin immunofluorescence. Exp Brain Res 1987 2
4 3208989 Thyroid hormone metabolism in neuron-enriched primary cultures of fetal rat brain cells. Mol Cell Endocrinol 1988 Jul 2
5 6173092 Brain primary culture-- a characterization (part II). Brain Res 1982 Jan 7 1
6 7589852 Effects of diabetes and hyperglycemia on the hexosamine synthesis pathway in rat muscle and liver. Diabetes 1995 Dec 6
7 8232303 Glucose regulation of transforming growth factor-alpha expression is mediated by products of the hexosamine biosynthesis pathway. Mol Endocrinol 1993 Aug 8
8 8285066 [Structural congeners of guanfu base A and their antiarrhythmic activity]. Yao Xue Xue Bao 1993 7
9 8593937 Regulation of glycogen synthase and protein phosphatase-1 by hexosamines. Diabetes 1996 Mar 7
10 9165041 Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin sensitive tissues. Endocrinology 1997 Jun 2
11 9453242 Effects of overexpression of glutamine:fructose-6-phosphate amidotransferase (GFAT) and glucosamine treatment on translocation of GLUT4 in rat adipose cells. Mol Cell Endocrinol 1997 Nov 30 4
12 9836513 Regulation of glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase. Diabetes 1998 Dec 1
13 10070007 Decreased hexosamine biosynthesis in GH-deficient dwarf rat muscle. reversal with GH, but not IGF-I, therapy. Am J Physiol 1999 Mar 1
14 10416827 Glutamine: fructose-6-phosphate amidotransferase activity and gene expression are regulated in a tissue-specific fashion in pregnant rats. Life Sci 1999 2
15 10604279 Insulin stimulation of glutamine: fructose-6-phosphate amidotransferase occurs via an insulin-like growth factor-1 pathway in rat fibroblasts. Res Commun Mol Pathol Pharmacol 1999 1
16 10830278 Overexpression of glutamine:fructose-6-phosphate amidotransferase in rat-1 fibroblasts enhances glucose-mediated glycogen accumulation via suppression of glycogen phosphorylase activity. Endocrinology 2000 Jun 18
17 10898949 Purification and characterization of glutamine:fructose 6-phosphate amidotransferase from rat liver. Arch Biochem Biophys 2000 Jul 15 4
18 10997914 Hexosamine regulation of glucose-mediated laminin synthesis in mesangial cells involves protein kinases A and C. Am J Physiol Renal Physiol 2000 Oct 6
19 11094865 Regulation of glutamine:fructose-6-phosphate amidotransferase activity by high glucose and transforming growth factor beta in rat mesangial cells. J Investig Med 2000 Nov 10
20 11274905 Glucose-induced insulin resistance of phosphatidylinositol 3'-OH kinase and AKT/PKB is mediated by the hexosamine biosynthesis pathway. J Diabetes Complications 2001 Mar-Apr 4
21 11390407 Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress. J Biol Chem 2001 Aug 17 1
22 11574420 Hexosamine-induced fibronectin protein synthesis in mesangial cells is associated with increases in cAMP responsive element binding (CREB) phosphorylation and nuclear CREB: the involvement of protein kinases A and C. Diabetes 2001 Oct 12
23 12579825 [Study on the metabolites of guanfu base A hydrochloride in rat urine by high performance liquid chromatograph-mass spectrum]. Yao Xue Xue Bao 2002 Apr 11
24 14972338 Adenovirus-mediated gene transfer of glutamine: fructose-6-phosphate amidotransferase antagonizes the effects of interleukin-1beta on rat chondrocytes. Osteoarthritis Cartilage 2004 Mar 2
25 16555472 Effect of sucrose and saturated-fat diets on mRNA levels of genes limiting muscle fatty acid and glucose supply in rats. Lipids 2006 Jan 3
26 16892452 Hexosamine induction of oxidative stress, hypertrophy and laminin expression in renal mesangial cells: effect of the anti-oxidant alpha-lipoic acid. Cell Biochem Funct 2007 Sep-Oct 3
27 17069847 Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels. J Mol Cell Cardiol 2007 Jan 8
28 18185980 Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway rats. Biogerontology 2008 Jun 1
29 18264122 Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway. Br J Pharmacol 2008 Apr 1
30 19936093 Proposed regulation of gene expression by glucose in rodent heart. Gene Regul Syst Bio 2007 Nov 5 2
31 20506529 Expression of GFAT1 and OGT in podocytes: transport of glucosamine and the implications for glucose uptake into these cells. J Cell Physiol 2010 Nov 6
32 20692926 Alterations in the glial fibrillary acidic protein content of primary astrocyte cultures for evaluation of glial cell toxicity. Toxicol In Vitro 1994 Jun 4
33 21958546 Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors. Bioorg Med Chem Lett 2011 Nov 1 4
34 23990361 TRIB3 mediates glucose-induced insulin resistance via a mechanism that requires the hexosamine biosynthetic pathway. Diabetes 2013 Dec 3
35 23995100 Differential vasomotor effects of insulin on gastrocnemius and soleus feed arteries in the OLETF rat model: role of endothelin-1. Exp Physiol 2014 Jan 2
36 25689466 Glutamine enema regulates colonic ubiquitinated proteins but not proteasome activities during TNBS-induced colitis leading to increased mitochondrial activity. Proteomics 2015 Jul 1
37 30062563 Safety, heart specificity, and therapeutic effect evaluation of Guanfu base A-loaded solid nanolipids in treating arrhythmia. Drug Deliv Transl Res 2018 Oct 1
38 30221662 O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats. Int J Mol Med 2018 Dec 3
39 30475578 The Inhibition by Guanfu Base A of Neuropathic Pain Mediated by P2Y<sub>12</sub> Receptor in Dorsal Root Ganglia. ACS Chem Neurosci 2019 Mar 20 1
40 30805403 The Effect of Vitamin D on Cellular Pathways of Diabetic Nephropathy. Rep Biochem Mol Biol 2019 Jan 2
41 34912841 CNS GNPDA2 Does Not Control Appetite, but Regulates Glucose Homeostasis. Front Nutr 2021 1