protein phosphatase 1 regulatory subunit 15A ; Homo sapiens






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1 9694816 The gamma134.5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high molecular weight complex with the enzyme in infected cells. J Biol Chem 1998 Aug 14 2
2 11163539 Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells. Free Radic Biol Med 2001 Jan 15 3
3 11241327 Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors. Int J Cancer 2001 Feb 20 1
4 11381086 Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. J Cell Biol 2001 May 28 1
5 11435585 Functional interaction between fluorodeoxyuridine-induced cellular alterations and replication of a ribonucleotide reductase-negative herpes simplex virus. J Virol 2001 Aug 2
6 11517336 Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis. Proc Natl Acad Sci U S A 2001 Aug 28 2
7 11564868 Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. Mol Cell Biol 2001 Oct 2
8 12114539 mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proc Natl Acad Sci U S A 2002 Jul 23 1
9 12504222 Selective cyclooxygenase-2 inhibitor rofecoxib (Vioxx) induces expression of cell cycle arrest genes and slows tumor growth in human pancreatic cancer. J Gastrointest Surg 2002 Nov-Dec 1
10 12556489 Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Mol Cell Biol 2003 Feb 3
11 12724406 Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. Mol Cell Biol 2003 May 2
12 14657671 Codon-optimized cloning, expression and characertization of the C-terminal region of human apoptotic protein GADD34 in Escherichia coli. Cell Cycle 2004 Jan 1
13 15031599 Mechanisms of paclitaxel-induced apoptosis in an ovarian cancer cell line and its paclitaxel-resistant clone. Oncology 2004 1
14 15059970 Up-regulation of GADD34 mediates the synergistic anticancer activity of mitomycin C and a gamma134.5 deleted oncolytic herpes virus (G207). FASEB J 2004 Jun 4
15 15492278 Modulation of gene expression in human central nervous system tumors under methionine deprivation-induced stress. Cancer Res 2004 Oct 15 1
16 16294031 Cisplatin-induced GADD34 upregulation potentiates oncolytic viral therapy in the treatment of malignant pleural mesothelioma. Cancer Biol Ther 2006 Jan 4
17 16325149 Role of GADD34 in modulation of cisplatin cytotoxicity. Biochem Pharmacol 2006 Jan 12 14
18 16391370 Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication. J Natl Cancer Inst 2006 Jan 4 4
19 16497877 Raloxifene-induced myeloma cell apoptosis: a study of nuclear factor-kappaB inhibition and gene expression signature. Mol Pharmacol 2006 May 1
20 16709241 Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer 2006 May 18 1
21 17548474 The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Mol Cell Biol 2007 Aug 1
22 18052927 A decrease in cellular energy status stimulates PERK-dependent eIF2alpha phosphorylation and regulates protein synthesis in pancreatic beta-cells. Biochem J 2008 Mar 15 1
23 18082618 CD437 induces apoptosis in ovarian adenocarcinoma cells via ER stress signaling. Biochem Biophys Res Commun 2008 Feb 15 2
24 18544642 Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines. Am J Physiol Endocrinol Metab 2008 Aug 3
25 18851785 [Impact of epigallocatechin gallate on gene expression profiles of human hepatocellular carcinoma cell lines BEL7404/ADM and BEL7402/5-FU]. Ai Zheng 2008 Oct 1
26 19148492 Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. Int J Oncol 2009 Feb 1
27 19190324 Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy. Cancer Res 2009 Feb 15 2
28 19302589 Amiloride derivatives induce apoptosis by depleting ER Ca(2+) stores in vascular endothelial cells. Br J Pharmacol 2009 Apr 1
29 19901557 Disruption of the PP1/GADD34 complex induces calreticulin exposure. Cell Cycle 2009 Dec 1
30 20022965 Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells. J Biol Chem 2010 Feb 26 3
31 20043261 Selenium decreases thyroid cancer cell growth by increasing expression of GADD153 and GADD34. Nutr Cancer 2010 1
32 21146245 ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes. J Hepatol 2011 Apr 1
33 21518769 Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein. J Biol Chem 2011 Jun 17 5
34 22315398 Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells. Proc Natl Acad Sci U S A 2012 Feb 21 6
35 22578158 Pegylated phospholipid micelles induce endoplasmic reticulum-dependent apoptosis of cancer cells but not normal cells. ACS Nano 2012 Jun 26 2
36 22926702 Anti-leukemic mechanisms of pegylated arginase I in acute lymphoblastic T-cell leukemia. Leukemia 2013 Mar 1
37 23243060 Induction of endoplasmic reticulum stress by sorafenib and activation of NF-κB by lestaurtinib as a novel resistance mechanism in Hodgkin lymphoma cell lines. Mol Cancer Ther 2013 Feb 1
38 23962237 Loss of Oca2 disrupts the unfolded protein response and increases resistance to endoplasmic reticulum stress in melanocytes. Pigment Cell Melanoma Res 2013 Nov 1
39 24092754 Phosphorylation at tyrosine 262 promotes GADD34 protein turnover. J Biol Chem 2013 Nov 15 7
40 24490819 Endoplasmic reticulum stress induced by zinc oxide nanoparticles is an earlier biomarker for nanotoxicological evaluation. ACS Nano 2014 Mar 25 1
41 25204313 Induction of GADD34 Regulates the Neurotoxicity of Amyloid β. Am J Alzheimers Dis Other Demen 2015 May 2
42 25386686 Inhibition of GADD34, the stress-inducible regulatory subunit of the endoplasmic reticulum stress response, does not enhance functional recovery after spinal cord injury. PLoS One 2014 1
43 25659802 GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy. Sci Rep 2015 Feb 9 8
44 25737469 An ATF4-Signal-Modulating Machine Other Than GADD34 Acts in ATF4-to-CHOP Signaling to Block CHOP Expression in ER-Stress-Related Autophagy. J Cell Biochem 2015 Jul 5
45 25774599 Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation. Elife 2015 Mar 16 1
46 26041779 Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity. J Biol Chem 2015 Jul 17 2
47 26134454 Crocin and Quercetin protect HCT116 and HEK293 cells from Zearalenone-induced apoptosis by reducing endoplasmic reticulum stress. Cell Stress Chaperones 2015 Nov 1
48 26163091 Is there a causal relationship between genetic changes and radiomics-based image features? An in vivo preclinical experiment with doxycycline inducible GADD34 tumor cells. Radiother Oncol 2015 Sep 1
49 26188073 Correction: Phosphatase Holoenzyme PP1/GADD34 Negatively Regulates TLR Response by Inhibiting TAK1 Serine 412 Phosphorylation. J Immunol 2015 Aug 1 1
50 26408692 GADD34 Facilitates Cell Death Resulting from Proteasome Inhibition. Anticancer Res 2015 Oct 3