free fatty acid receptor 4 ; Homo sapiens






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1 15619630 Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med 2005 Jan 1
2 16702987 Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol 2006 Jul 2
3 16978657 Monitoring ligand-mediated internalization of G protein-coupled receptor as a novel pharmacological approach. Life Sci 2006 Dec 3 1
4 17250804 The regulation of adipogenesis through GPR120. Biochem Biophys Res Commun 2007 Mar 9 1
5 18451539 Administration of perilla oil coated with Calshell increases glucagon-like peptide secretion. Biol Pharm Bull 2008 May 2
6 18775472 Oleic acid induces ERK1/2 activation and AP-1 DNA binding activity through a mechanism involving Src kinase and EGFR transactivation in breast cancer cells. Mol Cell Endocrinol 2008 Nov 6 1
7 19007110 Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists. J Med Chem 2008 Dec 11 2
8 19460454 Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis. Prostaglandins Other Lipid Mediat 2009 Sep 1
9 19723586 Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: comparison with human GPR120 splice variants. Comp Biochem Physiol B Biochem Mol Biol 2009 Dec 2
10 20471368 Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor. Biochem Biophys Res Commun 2010 Jun 11 16
11 20813253 Fishing out a sensor for anti-inflammatory oils. Cell 2010 Sep 3 1
12 21094898 K-cells and glucose-dependent insulinotropic polypeptide in health and disease. Vitam Horm 2010 1
13 21313786 [Ameliorative effect of n-3 fatty acid on insulin resistance through GPR120]. Nihon Yakurigaku Zasshi 2010 Dec 1
14 21376067 Nutrient sensing in the gut: interactions between chemosensory cells, visceral afferents and the secretion of satiation peptides. Physiol Behav 2011 Nov 30 1
15 21868624 G protein-coupled receptors in human fat taste perception. Chem Senses 2012 Feb 1
16 21998136 TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1. Am J Physiol Cell Physiol 2012 Jan 1 2
17 22300073 Recent advances in gut nutrient chemosensing. Curr Med Chem 2012 2
18 22343897 Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 2012 Feb 19 2
19 22453062 Nutrient sensing and signalling by the gut. Proc Nutr Soc 2012 Nov 1
20 22519963 Discovery of a potent and selective GPR120 agonist. J Med Chem 2012 May 10 1
21 22542696 Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs. Prog Lipid Res 2012 Jul 1
22 23060857 Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets. Front Endocrinol (Lausanne) 2012 1
23 23234236 Investigation of free fatty acid associated recombinant membrane receptor protein expression in HEK293 cells using Raman spectroscopy, calcium imaging, and atomic force microscopy. Anal Chem 2013 Feb 5 4
24 23317787 Free fatty acid receptor GPR120 and pathogenesis of obesity and type 2 diabetes mellitus. Prog Mol Biol Transl Sci 2013 3
25 23594480 The combined effects of genetic variations in the GPR120 gene and dietary fat intake on obesity risk. Biomed Res 2013 Apr 3
26 23831422 Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice. Neuroscience 2013 Oct 10 1
27 23849180 Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells. Lipids Health Dis 2013 Jul 13 11
28 23851494 Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma. Oncogene 2013 Dec 5 3
29 23862620 Free fatty acids-sensing G protein-coupled receptors in drug targeting and therapeutics. Curr Med Chem 2013 1
30 23932095 TGFβ-pathway is down-regulated in a uterine carcinosarcoma: a case study. Pathol Res Pract 2013 Nov 1
31 23993698 Phenotypic characterization of GPR120-expressing cells in the interstitial tissue of pancreas. Tissue Cell 2013 Dec 1
32 24094095 The therapeutic potential of GPR120: a patent review. Expert Opin Ther Pat 2013 Dec 2
33 24239485 Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation. Eur J Pharmacol 2014 Jan 15 8
34 24412271 Mechanisms of homologous and heterologous phosphorylation of FFA receptor 4 (GPR120): GRK6 and PKC mediate phosphorylation of Thr³⁴⁷, Ser³⁵⁰, and Ser³⁵⁷ in the C-terminal tail. Biochem Pharmacol 2014 Feb 15 18
35 24412488 CD36- and GPR120-mediated Ca²⁺ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice. Gastroenterology 2014 Apr 1
36 24505350 Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease. PLoS One 2014 3
37 24734983 Docosahexaenoic acid inhibits vascular endothelial growth factor (VEGF)-induced cell migration via the GPR120/PP2A/ERK1/2/eNOS signaling pathway in human umbilical vein endothelial cells. J Agric Food Chem 2014 May 7 3
38 24817122 Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4. J Biol Chem 2014 Jun 27 2
39 24876224 Lipid droplet formation in response to oleic acid in Huh-7 cells is mediated by the fatty acid receptor FFAR4. J Cell Sci 2014 Jul 15 2
40 24881566 Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg Med Chem Lett 2014 Jul 15 2
41 24913719 Effects of obesity/fatty acids on the expression of GPR120. Mol Nutr Food Res 2014 Sep 8
42 25076939 Omega-3 Fatty Acids and FFAR4. Front Endocrinol (Lausanne) 2014 4
43 25114508 Potential roles of GPR120 and its agonists in the management of diabetes. Drug Des Devel Ther 2014 2
44 25131623 Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4. Br J Pharmacol 2015 Jul 2
45 25250621 Novel association between a nonsynonymous variant (R270H) of the G-protein-coupled receptor 120 and liver injury in children and adolescents with obesity. J Pediatr Gastroenterol Nutr 2014 Oct 2
46 25274213 [Host energy regulation via SCFAs receptors, as dietary nutrition sensors, by gut microbiota]. Yakugaku Zasshi 2014 1
47 25303521 [Br]eaking FAt. Cell 2014 Oct 9 3
48 25303528 Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell 2014 Oct 9 1
49 25414667 Free fatty acid receptors as therapeutic targets for the treatment of diabetes. Front Pharmacol 2014 2
50 25641170 Proinflammatory effects of arachidonic acid in a lipopolysaccharide-induced inflammatory microenvironment in 3T3-L1 adipocytes in vitro. Appl Physiol Nutr Metab 2015 Feb 1