dopamine receptor D4 ; Homo sapiens






373 Article(s)
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1 1349574 The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS. Genomics 1992 May 2
2 1554689 The rat dopamine D4 receptor: sequence, gene structure, and demonstration of expression in the cardiovascular system. New Biol 1992 Feb 1
3 1840645 Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 1991 Apr 18 1
4 7475902 Is clozapine selective for the dopamine D4 receptor? Life Sci 1995 4
5 7552267 Dopamine D4 receptors and effects of guanine nucleotides on [3H]raclopride binding in postmortem caudate nucleus of subjects with schizophrenia or major depression. Brain Res 1995 May 29 5
6 7573171 DRD4 dopamine receptor genotype and CSF monoamine metabolites in Finnish alcoholics and controls. Am J Med Genet 1995 Jun 19 2
7 7643093 Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 1995 Sep 1
8 7737323 Modulation of the clozapine structure increases its selectivity for the dopamine D4 receptor. Eur J Pharmacol 1995 Feb 6 2
9 7752807 The antisecretory effects of clozapine, a dopamine D4 receptor antagonist, are blocked by the dopamine D1 receptor antagonist, SCH23390. Life Sci 1995 3
10 7766285 Plasma clozapine levels and the treatment of L-DOPA-induced psychosis in Parkinson's disease. A high potency effect of clozapine. Neuropsychopharmacology 1995 Feb 1
11 7831304 Variability of dopamine D4 receptor (DRD4) gene sequence within and among nonhuman primate species. Proc Natl Acad Sci U S A 1995 Jan 17 1
12 7861418 Binding of 5H-dibenzo[a,d]cycloheptene and dibenz[b,f]oxepin analogues of clozapine to dopamine and serotonin receptors. J Med Chem 1995 Feb 17 10
13 7909222 Analysis of the D4 dopamine receptor gene variant in an Italian schizophrenia kindred. Arch Gen Psychiatry 1994 Apr 1
14 7909310 A SmaI PCR-RFLP in the 5' noncoding region of the human D4 dopamine receptor gene (DRD4). Hum Hered 1994 Jan-Feb 1
15 7914460 Analysis of new D4 dopamine receptor (DRD4) coding region variants and TH microsatellite in the Old Order Amish family (OOA110). Psychiatr Genet 1994 Summer 1
16 7944879 Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine. Arch Gen Psychiatry 1994 Nov 5
17 7961573 An overview of the mechanism of action of clozapine. J Clin Psychiatry 1994 Sep 1
18 8005603 (G)n-mononucleotide polymorphism in the human D4 dopamine receptor (DRD4) gene. Hum Genet 1994 Jun 2
19 8064797 Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. J Med Chem 1994 Aug 19 3
20 8078498 Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes. Mol Pharmacol 1994 Aug 2
21 8093383 Dopamine D4 receptor subtypes and response to clozapine. Lancet 1993 Jan 9 1
22 8097160 Dopamine D4 receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective. Eur J Pharmacol 1993 Mar 16 4
23 8102973 Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications. Eur J Pharmacol 1993 Jun 4 5
24 8248849 Low density of dopamine D4 receptors in Parkinson's, schizophrenia, and control brain striata. Synapse 1993 Aug 4
25 8522958 Dopaminergic inhibition of catecholamine secretion from chromaffin cells: evidence that inhibition is mediated by D4 and D5 dopamine receptors. J Neurochem 1996 Jan 1
26 8523409 1-Phenyl-3-(aminomethyl)pyrroles as potential antipsychotic agents. Synthesis and dopamine receptor binding. J Med Chem 1995 Dec 8 2
27 8546161 Association study between the dopamine D4 receptor gene and schizophrenia. Am J Med Genet 1995 Oct 9 1
28 8566176 Deriving the therapeutic concentrations for clozapine and haloperidol: the apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing radioligand. Eur J Pharmacol 1995 Oct 15 6
29 8639513 Cryptic initiation at the human D4 receptor reveals a functional role for the amino terminus. Biochemistry 1996 Mar 19 1
30 8642550 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem 1996 May 10 1
31 8693618 [Dopamine D4-receptor variants, schizophrenia and clozapine therapy]. Ugeskr Laeger 1996 Jun 17 3
32 8741229 The importance of dopamine D4 receptors in the action and development of antipsychotic agents. Drugs 1996 Jan 2
33 8741875 Dopamine D4 receptor variant in Africans, D4valine194glycine, is insensitive to dopamine and clozapine: report of a homozygous individual. Am J Med Genet 1996 Jan 22 2
34 8746407 Identification of two novel polymorphisms and a rare deletion variant in the human dopamine D4 receptor gene. Psychiatr Genet 1995 Fall 1
35 8825892 Analysis of clozapine response and polymorphisms of the dopamine D4 receptor gene (DRD4) in schizophrenic patients. Am J Med Genet 1995 Dec 18 2
36 8854201 Dopamine and serotonin receptors: amino acid sequences, and clinical role in neuroleptic parkinsonism. Jpn J Pharmacol 1996 Jul 1
37 8863800 Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. J Med Chem 1996 Oct 11 1
38 8866760 Therapeutic receptor-blocking concentrations of neuroleptics. Int Clin Psychopharmacol 1995 Sep 1
39 8903944 Functional coupling of human D2, D3, and D4 dopamine receptors in HEK293 cells. J Recept Signal Transduct Res 1995 Jan-Mar 1
40 8914122 Efficacy and side-effects of clozapine: testing for association with allelic variation in the dopamine D4 receptor gene. Neuropsychopharmacology 1996 Nov 2
41 8957240 The naphtosultam derivative RP 62203 (fananserin) has high affinity for the dopamine D4 receptor. Eur J Pharmacol 1996 Oct 24 2
42 8968364 Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist. J Pharmacol Exp Ther 1996 Dec 1
43 8981420 YM-50001: a novel, potent and selective dopamine D4 receptor antagonist. Neuroreport 1996 Nov 4 1
44 9003072 Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor. J Neurochem 1997 Feb 2
45 9015795 Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors. Neuropsychopharmacology 1997 Feb 3
46 9028633 Light microscope autoradiography of peripheral dopamine receptor subtypes. Clin Exp Hypertens 1997 Jan-Feb 1
47 9098699 Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D4 receptor. Eur J Pharmacol 1997 Mar 19 2
48 9112381 Dopamine D4 receptor-mediated inhibition of cyclic adenosine 3',5'-monophosphate production does not affect prolactin regulation. Endocrinology 1997 May 3
49 9193198 The effects of a selective D4 dopamine receptor antagonist (L-745,870) in acutely psychotic inpatients with schizophrenia. D4 Dopamine Antagonist Group. Arch Gen Psychiatry 1997 Jun 3
50 9223608 Dopamine D4 receptor in human peripheral blood lymphocytes: a radioligand binding assay study. Neurosci Lett 1997 Jun 27 1