dihydrofolate reductase ; Mus musculus

248 Article(s)
Pub. Date
#Total Relationship(s)
1 959 Substrate and inhibitor complexes of dihydrofolate reductase from amethopterin-resistant L1210 cells. Arch Biochem Biophys 1975 Dec 1
2 216671 Polyoma virus and cyclic AMP-mediated control of dihydrofolate reductase mRNA abundance in methotrexate-resistant mouse fibroblasts. J Biol Chem 1979 Jan 25 14
3 288069 Regulation of dihydrofolate reductase synthesis in an overproducing 3T6 cell line during transition from resting to growing state. Proc Natl Acad Sci U S A 1979 Jun 5
4 360074 Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. Nature 1978 Oct 19 1
5 432641 Liposomes and local hyperthermia: selective delivery of methotrexate to heated tumors. Science 1979 Apr 13 1
6 500787 Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells. J Cell Biol 1979 Nov 9
7 638018 Effect of interaction between methotrexate and dihydrofolate reductase on DNA synthesis in L1210 cells in vitro. Br J Cancer 1978 Mar 3
8 803254 Pharmacology of a new triazine antifolate in mice, rats, dogs, and monkeys. Cancer Res 1975 Jan 2
9 1350785 Purification and characterization of the neu/erb B2 ligand-growth factor from bovine kidney. J Biol Chem 1992 Jun 5 1
10 1378536 Mechanism of induction of micronuclei and chromosome aberrations in mouse bone marrow by multiple treatments of methotrexate. Mutat Res 1992 Aug 4
11 1409968 Amplification of plasmid (L factor) DNA and increased production of a plasmid gene product (gamma-interferon) in mouse L cells. Plasmid 1992 Sep 4
12 1446834 The use of a wild-type dihydrofolate reductase-encoding cDNA as a dominant selectable marker and induction of expression by methotrexate. Gene 1992 Nov 16 5
13 1489988 Assay for expression of methotrexate-resistant dihydrofolate reductase activity in the presence of drug-sensitive enzyme. J Pharmacol Toxicol Methods 1992 Nov 2
14 1510969 Complementary perturbation of the kinetic mechanism and catalytic effectiveness of dihydrofolate reductase by side-chain interchange. Biochemistry 1992 Sep 1 2
15 1525211 Comparison of the expression of a mutant dihydrofolate reductase under control of different internal promoters in retroviral vectors. Hum Gene Ther 1992 Aug 5
16 1533575 Simultaneous changes in various mechanisms that mediate the cell incorporation of folate compounds account for low levels of resistance to methotrexate. Cell Biochem Funct 1992 Mar 4
17 1562458 DNA fragmentation, dATP pool elevation and potentiation of antifolate cytotoxicity in L1210 cells by hypoxanthine. Br J Cancer 1992 Apr 3
18 1620104 Molecular structure and evolution of double-minute chromosomes in methotrexate-resistant cultured mouse cells. Mol Cell Biol 1992 Jul 1
19 1630919 Analysis of DNA damage and repair in murine leukemia L1210 cells using a quantitative polymerase chain reaction assay. Nucleic Acids Res 1992 Jul 11 1
20 1699288 Deregulation of DNA polymerase beta by sense and antisense RNA expression in mouse 3T3 cells alters cell growth. Somat Cell Mol Genet 1990 Jul 1
21 1713479 Transgenic rice cell lines and plants: expression of transferred chimeric genes. Plant Mol Biol 1991 May 2
22 1732549 Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin. J Med Chem 1992 Jan 24 2
23 1732551 Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin. J Med Chem 1992 Jan 24 2
24 1768258 Antifolates induce primary inhibition of the de novo purine pathway prior to 5-aminoimidazole-4-carboxamide ribotide transformylase in leukemia cells. Biochem Int 1991 May 10
25 1782010 Evidence for kinetic and immunologic heterogeneity of dihydrofolate reductase in L1210 leukemia cells. Biochem Med Metab Biol 1991 Oct 10
26 1939053 Trimethoprim binds in a bacterial mode to the wild-type and E30D mutant of mouse dihydrofolate reductase. J Biol Chem 1991 Oct 25 1
27 1967217 Serial transplantation of methotrexate-resistant bone marrow: protection of murine recipients from drug toxicity by progeny of transduced stem cells. Blood 1990 Jan 15 1
28 1967605 Structural similarities among enzyme pterin binding sites as demonstrated by a monoclonal anti-idiotypic antibody. J Biol Chem 1990 Feb 5 1
29 1995880 Synthesis and biological activity of methotrexate analogues with two acid groups and a hydrophobic aromatic ring in the side chain. J Med Chem 1991 Feb 1
30 2040628 The C terminus of mouse ornithine decarboxylase confers rapid degradation on dihydrofolate reductase. Support for the pest hypothesis. J Biol Chem 1991 Jun 15 1
31 2122527 X-ray induction of methotrexate resistance due to dhfr gene amplification. Somat Cell Mol Genet 1990 Sep 3
32 2131041 Hypersensitivity to low level cytotoxic stress in mouse cells with high levels of DHFR gene amplification. Anticancer Drugs 1990 Oct 2
33 2206778 Preferential selection during therapy in vivo by edatrexate compared to methotrexate of resistant L1210 cell variants with decreased folylpolyglutamate synthetase activity. Cancer Commun 1990 1
34 2263462 Isolation and characterization of a variant dihydrofolate reductase cDNA from methotrexate-resistant murine L5178Y cells. Nucleic Acids Res 1990 Dec 11 8
35 2277081 A cell cycle analysis of growth-related genes expressed during T lymphocyte maturation. J Cell Biol 1990 Dec 2
36 2299633 Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid. J Med Chem 1990 Feb 1
37 2302716 Interspecific DNA-mediated transfer and amplification of a gene specifying a Mr 100,000 human melanoma-associated cell surface glycoprotein. Cancer Res 1990 Mar 1 3
38 2395644 Analysis and in vitro localization of internal methylated adenine residues in dihydrofolate reductase mRNA. Nucleic Acids Res 1990 Aug 25 1
39 2396254 The changes in the levels of dihydrofolate reductase mRNA and its gene dosage in 5-fluorouracil-resistant L1210 cells. Tohoku J Exp Med 1990 May 4
40 2401371 Transfection of DHFR- and DHFR+ mammalian cells using methotrexate-resistant mutants of mouse dihydrofolate reductase. FEBS Lett 1990 Sep 3 2
41 2423690 Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid. J Med Chem 1986 Jun 2
42 2467676 Further studies on the pharmacologic effects of the 7-hydroxy catabolite of methotrexate in the L1210 murine leukemia cell. Biochem Pharmacol 1989 Mar 1 2
43 2476667 Transcriptional mapping of the amplified region encoding the dihydrofolate reductase-thymidylate synthase of Leishmania major reveals a high density of transcripts, including overlapping and antisense RNAs. Mol Cell Biol 1989 Sep 1
44 2478419 Amplification of multicistronic plasmids in the human 293 cell line and secretion of correctly processed recombinant human protein C. Gene 1989 Sep 1 3
45 2480860 Expression of a methotrexate resistant dihydrofolate reductase gene in transgenic mice. Dev Genet 1989 3
46 2484623 Mechanisms of arsenic-induced cell transformation. Biol Trace Elem Res 1989 Jul-Sep 3
47 2668417 A new tool for the serodiagnosis of acute Plasmodium falciparum malaria in individuals with primary infection. J Immunol Methods 1989 Aug 15 1
48 2674679 Dual bidirectional promoters at the mouse dhfr locus: cloning and characterization of two mRNA classes of the divergently transcribed Rep-1 gene. Mol Cell Biol 1989 Jul 1
49 2710119 Chimeric 3-hydroxy-3-methylglutaryl coenzyme A reductase-dihydrofolate reductase genes display bidirectional expression and unidirectional regulation in stably transfected cells. Mol Cell Biol 1989 Feb 2
50 2736529 Enhancement of the frequency of methotrexate resistance by gamma-radiation in Chinese hamster ovary and mouse 3T6 cells. Cancer Res 1989 Jul 15 1