| 1 | 20842748 | Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutières syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression. | Hum Mutat | 2010 Nov |
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| 2 | 22056990 | HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. | Nature | 2011 Nov 6 |
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| 3 | 22069334 | Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase. | J Biol Chem | 2011 Dec 23 |
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| 4 | 22327569 | SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. | Nat Immunol | 2012 Feb 12 |
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| 5 | 22341459 | SAMHD1 Joins the red Queen's court. | Cell Host Microbe | 2012 Feb 16 |
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| 6 | 22908011 | SAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx Protein. | Front Microbiol | 2012 |
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| 7 | 22926205 | Restricting HIV the SAMHD1 way: through nucleotide starvation. | Nat Rev Microbiol | 2012 Oct |
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| 8 | 22973040 | The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus. | J Virol | 2012 Dec |
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| 9 | 22978176 | [Research progress of the anti-HIV activity of SAMHD1]. | Bing Du Xue Bao | 2012 Jun |
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| 10 | 23062609 | Lentivirus Vpr and Vpx accessory proteins usurp the cullin4-DDB1 (DCAF1) E3 ubiquitin ligase. | Curr Opin Virol | 2012 Dec |
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| 11 | 23092512 | Identification and characterization of naturally occurring splice variants of SAMHD1. | Retrovirology | 2012 Oct 23 |
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| 12 | 23135508 | SAMHD1 does it again, now in resting T cells. | Nat Med | 2012 Nov |
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| 13 | 23231760 | SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons. | Retrovirology | 2012 Dec 11 |
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| 14 | 23260109 | Intracellular nucleotide levels and the control of retroviral infections. | Virology | 2013 Feb 20 |
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| 15 | 23269793 | SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells. | J Virol | 2013 Mar |
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| 16 | 23364794 | Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction. | J Biol Chem | 2013 Mar 22 |
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| 17 | 23371319 | Single-stranded nucleic acids promote SAMHD1 complex formation. | J Mol Med (Berl) | 2013 Jun |
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| 18 | 23426366 | Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. | J Biol Chem | 2013 Apr 12 |
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| 19 | 23442224 | Evidence for IFNα-induced, SAMHD1-independent inhibitors of early HIV-1 infection. | Retrovirology | 2013 Feb 25 |
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| 20 | 23497255 | Restriction of diverse retroviruses by SAMHD1. | Retrovirology | 2013 Mar 5 |
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| 21 | 23497353 | Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply. | Retrovirology | 2013 Mar 11 |
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| 22 | 23564003 | Metabolic pathways as regulators of HIV infection. | Curr Opin HIV AIDS | 2013 May |
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| 23 | 23601106 | The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation. | Cell Host Microbe | 2013 Apr 17 |
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| 24 | 23602554 | Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1. | Cell Rep | 2013 Apr 25 |
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| 25 | 23677995 | HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation. | J Biol Chem | 2013 Jun 28 |
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| 26 | 23744077 | Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels. | J Biol Chem | 2013 Jul 12 |
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| 27 | 23825958 | Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells. | PLoS Pathog | 2013 |
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| 28 | 23858451 | The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells. | Proc Natl Acad Sci U S A | 2013 Aug 27 |
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| 29 | 23872947 | SAMHD1-dependent retroviral control and escape in mice. | EMBO J | 2013 Sep 11 |
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| 30 | 23880768 | GTP is the primary activator of the anti-HIV restriction factor SAMHD1. | J Biol Chem | 2013 Aug 30 |
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| 31 | 23924154 | HIV type 1 infection of plasmacytoid and myeloid dendritic cells is restricted by high levels of SAMHD1 and cannot be counteracted by Vpx. | AIDS Res Hum Retroviruses | 2014 Feb |
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| 32 | 23966382 | Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1. | J Virol | 2013 Nov |
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| 33 | 23972988 | Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response. | Cell Rep | 2013 Aug 29 |
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| 34 | 23986575 | Inhibition of CUL4A Neddylation causes a reversible block to SAMHD1-mediated restriction of HIV-1. | J Virol | 2013 Nov |
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| 35 | 24067963 | SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication. | J Virol | 2013 Dec |
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| 36 | 24139400 | Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis. | Cell Host Microbe | 2013 Oct 16 |
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| 37 | 24141705 | Mechanism of allosteric activation of SAMHD1 by dGTP. | Nat Struct Mol Biol | 2013 Nov |
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| 38 | 24155378 | A first-in-class NAE inhibitor, MLN4924, blocks lentiviral infection in myeloid cells by disrupting neddylation-dependent Vpx-mediated SAMHD1 degradation. | J Virol | 2014 Jan |
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| 39 | 24161438 | SAMHD1 host restriction factor: a link with innate immune sensing of retrovirus infection. | J Mol Biol | 2013 Dec 13 |
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| 40 | 24217394 | Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase. | Nat Commun | 2013 |
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| 41 | 24219908 | Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1. | Retrovirology | 2013 Nov 12 |
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| 42 | 24257155 | SAMHD1 knockout mice: modeling retrovirus restriction in vivo. | Retrovirology | 2013 Nov 20 |
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| 43 | 24317272 | Identification of natural splice variants of SAMHD1 in virus-infected HCC. | Oncol Rep | 2014 Feb |
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| 44 | 24336198 | Structural basis of lentiviral subversion of a cellular protein degradation pathway. | Nature | 2014 Jan 9 |
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| 45 | 24352659 | Host SAMHD1 protein promotes HIV-1 recombination in macrophages. | J Biol Chem | 2014 Jan 31 |
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| 46 | 24445253 | SAMHD1 prevents autoimmunity by maintaining genome stability. | Ann Rheum Dis | 2015 Mar |
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| 47 | 24485168 | Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration. | Retrovirology | 2014 Feb 1 |
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| 48 | 24623419 | Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1. | J Virol | 2014 May |
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| 49 | 24712655 | Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation. | Retrovirology | 2014 Apr 8 |
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| 50 | 24719410 | Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex. | J Virol | 2014 Jun |
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