Leukotriene A4






110 Article(s)
Download
PMID
Title
Journal
Pub. Date
#Total Relationship(s)
51 9620944 Cell biology of the 5-lipoxygenase pathway Am J Respir Crit Care Med 1998 Jun 2
52 9647604 Cell biology of the 5-lipoxygenase pathway. Am J Respir Crit Care Med 1998 Jun 2
53 9738935 Evidence for a leukotriene A4 hydrolase in Xenopus laevis skin exudate. FEBS Lett 1998 Aug 14 2
54 9988463 Pharmacogenetics of the 5-lipoxygenase pathway in asthma. Clin Exp Allergy 1998 Nov 1
55 10395897 Mouse leukotriene A4 hydrolase is expressed at high levels in intestinal crypt cells and splenic lymphocytes. Gene 1999 Jul 8 1
56 10467730 Aminopeptidase B (EC 3.4.11.6). Int J Biochem Cell Biol 1999 Jul 1
57 10591081 The biology of 5-lipoxygenase: function, structure, and regulatory mechanisms. Proc Assoc Am Physicians 1999 Nov-Dec 1
58 10601658 Increased leukotriene A(4) hydrolase expression in the heart of angiotensin II-induced hypertensive rat. FEBS Lett 1999 Dec 10 1
59 10691697 Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase. J Med Chem 2000 Feb 24 1
60 10864449 Covalent binding of LTA(4) to nucleosides and nucleotides. Arch Biochem Biophys 2000 Jul 1 2
61 10940725 Reciprocal regulation of LTA(4) hydrolase expression in human monocytes by gamma-interferon and interleukins 4 and 13: potential relevance to leukotriene regulation in glomerular disease. Exp Nephrol 2000 Jul-Oct 1
62 11087405 Alterations in leukotriene synthase activity of the human 5-lipoxygenase by site-directed mutagenesis affecting its positional specificity. Biochemistry 2000 Nov 28 2
63 11160764 Regulation of leukotrienes in the management of asthma: biology and clinical therapy. Annu Rev Med 2001 1
64 11601994 Saccharomyces cerevisiae leukotriene A4 hydrolase: formation of leukotriene B4 and identification of catalytic residues. Biochemistry 2001 Oct 23 3
65 11796736 Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase. J Biol Chem 2002 Apr 12 2
66 11802780 Nuclear-localization-signal-dependent and nuclear-export-signal-dependent mechanisms determine the localization of 5-lipoxygenase. Biochem J 2002 Feb 1 2
67 11936363 Pathogenesis of septic shock: implications for prevention and treatment. J Chemother 2001 Nov 5
68 12895593 Leukotriene C(4) synthase. Prostaglandins Leukot Essent Fatty Acids 2003 Aug-Sep 1
69 14637132 Molecular and catalytic properties of three rat leukotriene C(4) synthase homologs. Biochem Biophys Res Commun 2003 Dec 12 1
70 14676186 Stabilization of leukotriene A4 by epithelial fatty acid-binding protein in the rat basophilic leukemia cell. J Biol Chem 2004 Feb 27 2
71 15342681 Fatty acid binding proteins stabilize leukotriene A4: competition with arachidonic acid but not other lipoxygenase products. J Lipid Res 2004 Nov 2
72 16143298 Synthesis of 8,9-leukotriene A4 by murine 8-lipoxygenase. Biochem Biophys Res Commun 2005 Dec 9 1
73 16480927 TNF alpha production to TLR2 ligands in active IBD patients. Clin Immunol 2006 May 1
74 16924104 Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. Proc Natl Acad Sci U S A 2006 Aug 29 1
75 16968946 Eicosanoid transcellular biosynthesis: from cell-cell interactions to in vivo tissue responses. Pharmacol Rev 2006 Sep 1
76 17376394 Development of a fluorescence-based enzyme assay of human 5-lipoxygenase. Anal Biochem 2007 May 15 2
77 17623009 Biosynthesis and metabolism of leukotrienes. Biochem J 2007 Aug 1 1
78 18022234 Autoregulation mechanism of human neutrophil apoptosis during bacterial infection. Mol Immunol 2008 Apr 1
79 18042000 Leukotriene B4 receptor antagonists as therapeutics for inflammatory disease: preclinical and clinical developments. Expert Opin Investig Drugs 2007 Dec 1
80 18440824 High-level expression, purification, and crystallization of recombinant rat leukotriene C(4) synthase from the yeast Pichia pastoris. Protein Expr Purif 2008 Jul 2
81 18539590 Crystal structure of the cold-active aminopeptidase from Colwellia psychrerythraea, a close structural homologue of the human bifunctional leukotriene A4 hydrolase. J Biol Chem 2008 Aug 22 1
82 18616291 Leukotriene A4 metabolites are endogenous ligands for the Ah receptor. Biochemistry 2008 Aug 12 1
83 18674901 Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors. Bioorg Med Chem Lett 2008 Aug 15 1
84 19351866 Trovafloxacin enhances the inflammatory response to a Gram-negative or a Gram-positive bacterial stimulus, resulting in neutrophil-dependent liver injury in mice. J Pharmacol Exp Ther 2009 Jul 1
85 20400503 Leukotriene B4 is a physiologically relevant endogenous peroxisome proliferator-activated receptor-alpha agonist. J Biol Chem 2010 Jul 16 2
86 21146536 A leukotriene A4 hydrolase-related aminopeptidase from yeast undergoes induced fit upon inhibitor binding. J Mol Biol 2011 Feb 11 1
87 22913921 In silico modeling of the molecular structure and binding of leukotriene A4 into leukotriene A4 hydrolase. Chem Biol Drug Des 2012 Dec 1
88 23242647 Biosynthesis, isolation, and NMR analysis of leukotriene A epoxides: substrate chirality as a determinant of the cis or trans epoxide configuration. J Lipid Res 2013 Mar 1
89 24787654 Characterization and bioactivity of hepcidin-2 in zebrafish: dependence of antibacterial activity upon disulfide bridges. Peptides 2014 Jul 1
90 24893149 ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid. Biochemistry 2014 Jul 15 2
91 24974917 The catalytic formation of leukotriene C4: a critical step in inflammatory processes. Phys Chem Chem Phys 2014 Aug 14 2
92 25034252 Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis. Proc Natl Acad Sci U S A 2014 Aug 5 1
93 25128739 Hispolon inhibition of inflammatory apoptosis through reduction of iNOS/NO production via HO-1 induction in macrophages. J Ethnopharmacol 2014 Oct 28 1
94 27033421 Impact of simultaneous stimulation of 5-lipoxygenase and myeloperoxidase in human neutrophils. Prostaglandins Leukot Essent Fatty Acids 2016 Apr 2
95 27477678 Development of smart cell-free and cell-based assay systems for investigation of leukotriene C<sub>4</sub> synthase activity and evaluation of inhibitors. Biochim Biophys Acta 2016 Nov 3
96 28132911 Effect of alpha lipoic acid on leukotriene A<sub>4</sub> hydrolase. Eur J Pharmacol 2017 Mar 15 1
97 30058075 Leukotriene A4 hydrolase: an emerging target of natural products for cancer chemoprevention and chemotherapy. Ann N Y Acad Sci 2018 Nov 2
98 30291962 A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein. Biochim Biophys Acta Mol Cell Biol Lipids 2019 Apr 1
99 30606731 Lysophospholipid acyltransferases and leukotriene biosynthesis: intersection of the Lands cycle and the arachidonate PI cycle. J Lipid Res 2019 Feb 1
100 32247045 Molecular cloning, characterization and expression profiles of CD2AP in Nile tilapia (Oreochromis niloticus) responding to Streptococcus agalactiae infection and interaction with CD2 cytoplasmic segment. Fish Shellfish Immunol 2020 Jun 2