methyl 4-(adenin-9-yl)-2-hydroxybutanoate






10 Article(s)
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1 16326921 S-adenosyl-L-homocysteine hydrolase inactivation curtails ovalbumin-induced immune responses. J Pharmacol Exp Ther 2006 Mar 6
2 16914558 A reversible S-adenosyl-L-homocysteine hydrolase inhibitor ameliorates experimental autoimmune encephalomyelitis by inhibiting T cell activation. J Pharmacol Exp Ther 2006 Nov 9
3 21515785 An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling. J Immunol 2011 Jun 1 1
4 23583916 Critical role of transmethylation in TLR signaling and systemic lupus erythematosus. Clin Immunol 2013 May 1
5 24374810 Therapeutic effects of DZ2002, a reversible SAHH inhibitor, on lupus-prone NZB×NZW F1 mice via interference with TLR-mediated APC response. Acta Pharmacol Sin 2014 Feb 17
6 29155016 Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-α/IFN-γ-induced inflammatory response in keratinocytes and T cell-derived IL-17. Pharmacol Res 2018 Mar 15
7 30696480 Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage. Arthritis Res Ther 2019 Jan 29 9
8 30740254 Assay development for determination of DZ2002, a new reversible SAHH inhibitor, and its acid metabolite DZA in blood and application to rat pharmacokinetic study. J Pharm Anal 2019 Feb 3
9 33412493 DZ2002 alleviates psoriasis-like skin lesions via differentially regulating methylation of GATA3 and LCN2 promoters. Int Immunopharmacol 2021 Feb 10
10 33437781 Inhibition of S-adenosyl-L-homocysteine hydrolase alleviates alloimmune response by down-regulating CD4<sup>+</sup> T-cell activation in a mouse heart transplantation model. Ann Transl Med 2020 Dec 1