Title : Critical role of transmethylation in TLR signaling and systemic lupus erythematosus.

Pub. Date : 2013 May

PMID : 23583916






1 Functional Relationships(s)
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1 Here, we demonstrate that transmethylation inhibition by a reversible S-adenosyl-l-homocysteine hydrolase inhibitor (DZ2002) led to immunosuppression by reducing TLR-, B cell receptor (BCR)- and TCR-induced activation of immune cells, most likely by blocking NF-kappaB activity. methyl 4-(adenin-9-yl)-2-hydroxybutanoate T cell receptor alpha variable 6-3 Mus musculus