4-phenylbutyric acid






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1 2548207 Highly potent analogues of luteinizing hormone-releasing hormone containing D-phenylalanine nitrogen mustard in position 6. Proc Natl Acad Sci U S A 1989 Aug 2
2 7346381 [Degradation of L-phenylalanine and of aromatic carboxylic acids by chloridazon-degrading bacteria. Combination of side chain degradation and dioxygenase pathway]. Hoppe Seylers Z Physiol Chem 1981 Sep 1
3 7528572 Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial. Blood 1995 Jan 1 1
4 7691251 Enhanced fetal hemoglobin production by phenylacetate and 4-phenylbutyrate in erythroid precursors derived from normal donors and patients with sickle cell anemia and beta-thalassemia. Blood 1993 Oct 1 1
5 8412748 Restoration of nitrogen homeostasis in a man with ornithine transcarbamylase deficiency. Metabolism 1993 Oct 2
6 9006341 Resistance to cerebral malaria in tumor necrosis factor-alpha/beta-deficient mice is associated with a reduction of intercellular adhesion molecule-1 up-regulation and T helper type 1 response. Am J Pathol 1997 Jan 1
7 9366560 In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR. J Clin Invest 1997 Nov 15 3
8 9476862 A pilot clinical trial of oral sodium 4-phenylbutyrate (Buphenyl) in deltaF508-homozygous cystic fibrosis patients: partial restoration of nasal epithelial CFTR function. Am J Respir Crit Care Med 1998 Feb 1
9 9499451 Cytotoxic effects of sodium phenylbutyrate on human neuroblastoma cell lines. Int J Oncol 1998 Apr 1
10 9668530 Hemoglobin switching protocols in thalassemia. Experience with sodium phenylbutyrate and hydroxyurea. Ann N Y Acad Sci 1998 Jun 30 1
11 9809549 Gene redundancy and pharmacological gene therapy: implications for X-linked adrenoleukodystrophy. Nat Med 1998 Nov 1
12 10545613 Synergistic effect of histone hyperacetylation and DNA demethylation in the reactivation of the FMR1 gene. Hum Mol Genet 1999 Nov 1
13 10666019 Focus on "Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR". Am J Physiol Cell Physiol 2000 Feb 2
14 10666020 Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR. Am J Physiol Cell Physiol 2000 Feb 3
15 10716247 Pharmacological induction of peroxisomes in peroxisome biogenesis disorders. Ann Neurol 2000 Mar 1
16 10720936 Pharmacologic restoration of delta F508 CFTR-mediated chloride current. Kidney Int 2000 Mar 1
17 10778977 A novel approach for nasopharyngeal carcinoma treatment uses phenylbutyrate as a protein kinase C modulator: implications for radiosensitization and EBV-targeted therapy. Clin Cancer Res 2000 Apr 1
18 10853862 Activation of deltaF508 CFTR in a cystic fibrosis respiratory epithelial cell line by 4-phenylbutyrate, genistein and CPX. Eur Respir J 2000 May 3
19 11148526 Ornithine transcarbamylase deficiency and pancreatitis. J Pediatr 2001 Jan 1
20 11164382 Direct block of the cystic fibrosis transmembrane conductance regulator Cl(-) channel by butyrate and phenylbutyrate. Eur J Pharmacol 2001 Jan 12 4
21 11286510 Long-term treatment with sodium phenylbutyrate in ornithine transcarbamylase-deficient patients. Mol Genet Metab 2001 Apr 1
22 11404244 Sodium 4-phenylbutyrate downregulates HSC70 expression by facilitating mRNA degradation. Am J Physiol Lung Cell Mol Physiol 2001 Jul 2
23 11404246 Induction of HSP70 promotes DeltaF508 CFTR trafficking. Am J Physiol Lung Cell Mol Physiol 2001 Jul 2
24 11592822 Evaluation of pharmacological induction of fatty acid beta-oxidation in X-linked adrenoleukodystrophy. Mol Genet Metab 2001 Sep-Oct 4
25 11773060 Genistein restores functional interactions between Delta F508-CFTR and ENaC in Xenopus oocytes. J Biol Chem 2002 Mar 15 1
26 12095312 Evidence of CFTR function in cystic fibrosis after systemic administration of 4-phenylbutyrate. Mol Ther 2002 Jul 1
27 12161816 The peroxisome proliferator phenylbutyric acid (PBA) protects astrocytes from ts1 MoMuLV-induced oxidative cell death. J Neurovirol 2002 Aug 2
28 12241121 Complete response of a recurrent, multicentric malignant glioma in a patient treated with phenylbutyrate. J Neurooncol 2002 Sep 1
29 12417726 PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation. Mol Cell Biol 2002 Dec 1
30 12678732 Histone deacetylase inhibitors and anticancer therapy. Curr Med Chem Anticancer Agents 2002 Jul 1
31 14528273 Epigenetic targets in hematopoietic malignancies. Oncogene 2003 Sep 29 1
32 14560316 Phenylbutyrate increases SMN expression in vitro: relevance for treatment of spinal muscular atrophy. Eur J Hum Genet 2004 Jan 2
33 15093585 Histone deacetylase inhibitor 4-phenylbutyrate modulates glial fibrillary acidic protein and connexin 43 expression, and enhances gap-junction communication, in human glioblastoma cells. Eur J Cancer 2004 May 5
34 15118762 Histone deacetylase inhibitors upregulate expression of the coxsackie adenovirus receptor (CAR) preferentially in bladder cancer cells. Cancer Gene Ther 2004 Jul 1
35 15138583 Histone deacetylase inhibitor 4-phenylbutyrate suppresses GAPDH mRNA expression in glioma cells. Int J Oncol 2004 Jun 5
36 15178489 Eukaryotic initiation factor 2-associated glycoprotein, p67, shows differential effects on the activity of certain kinases during serum-starved conditions. Arch Biochem Biophys 2004 Jul 1 1
37 15226415 Sodium 4-phenylbutyrate protects against cerebral ischemic injury. Mol Pharmacol 2004 Oct 1
38 15295099 Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17. Proc Natl Acad Sci U S A 2004 Aug 17 1
39 15389886 Sodium 4-phenylbutyrate induces apoptosis of human lung carcinoma cells through activating JNK pathway. J Cell Biochem 2004 Nov 1 11
40 15490173 Activity of the yeast Tat2p tryptophan permease is sensitive to the anti-tumor agent 4-phenylbutyrate. Curr Genet 2004 Nov 3
41 15517883 Inhibition of cell proliferation by potential peroxisome proliferator-activated receptor (PPAR) gamma agonists and antagonists. Anticancer Res 2004 Sep-Oct 3
42 15523494 Phenylbutyrate increases SMN gene expression in spinal muscular atrophy patients. Eur J Hum Genet 2005 Feb 3
43 15572843 [Protective effects of HRD1 and 4-phenylbutyric acid against neuronal cell death]. Nihon Yakurigaku Zasshi 2004 Dec 8
44 15919480 Attenuation of primary nonfunction for syngeneic islet graft using sodium 4-phenylbutyrate. Transplant Proc 2005 May 1
45 16135773 Mutant tamm-horsfall glycoprotein accumulation in endoplasmic reticulum induces apoptosis reversed by colchicine and sodium 4-phenylbutyrate. J Am Soc Nephrol 2005 Oct 1
46 16246228 Effects of sodium phenylbutyrate on differentiation and induction of the P21WAF1/CIP1 anti-oncogene in human liver carcinoma cell lines. Chin J Dig Dis 2005 4
47 16415354 Functional and trafficking defects in ATP binding cassette A3 mutants associated with respiratory distress syndrome. J Biol Chem 2006 Apr 7 1
48 16472777 Novel short chain fatty acids restore chloride secretion in cystic fibrosis. Biochem Biophys Res Commun 2006 Mar 31 1
49 16621797 Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications. J Biol Chem 2006 Jun 23 3
50 16738016 Phosphorylation of S955 at the protein kinase A consensus promotes maturation of the alpha subunit of the colonic H+,K+ -ATPase. J Am Soc Nephrol 2006 Jul 1